DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3168 and sv2ba

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001076464.1	Gene:	sv2ba / 100009626	ZFINID:	ZDB-GENE-070209-134	Length:	689	Species:	Danio rerio

Alignment Length:	708	Identity:	194/708 - (27%)
Similarity:	302/708 - (42%)	Gaps:	132/708 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QPNYNQSAASNQASNHPT-GQANAPATGNATSHIDNRAIIQPYSLGTGPKQPEYQFAAD-NRGY- 82
            |.|.||     |...:|| |:.     |..|         .||.... |:|.|...|:| ..|:
Zfish     6 QNNINQ-----QGEAYPTYGEG-----GEYT---------YPYQTDY-PRQEEDDAASDATEGHD 50

  Fly    83 EPDSHANGKQQDVERDAPDGGHGGHGPPGKGGKGGKGRKK---SVPLPEPTAPIVANFERAIELC 144
            |.|....|:.|.|.       |.......:.....:.|.|   :..:.|.|.|  ..:|..:|.|
Zfish    51 EDDQMYEGEYQGVP-------HPDEIKEARRAARREARMKARMAAEVEEETLP--DQYESIMEDC 106

  Fly   145 GYGKFHYILLAICGLVSTSEEMDVISMSFILPSAECDLDLNTETKGWLNSIIFIGMMVGAYFWGS 209
            |:|:|.:.|..:.||...::.::...:||.|||||.|:.|:...||.|..|:::|||:||..||.
Zfish   107 GHGRFQWTLFTLLGLALMADGVECFVVSFALPSAEKDMCLSNADKGMLGLIVYVGMMIGAVVWGG 171

  Fly   210 IADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKR 274
            :||..|||:.|:....:|......|.|:|.|.||:.||..:|..:|||.||:::|:|||....||
Zfish   172 LADKLGRKQCLLYALAINCIFSFLSCFAQGYGFFIFFRLCSGIGIGGSIPVVYTYYAEFLQMDKR 236

  Fly   275 GSMLSFMAAFWTFGNLFVASLAWLIIPR-TIGFTT-PYFTYNSWRIFLLVCSLPSFLVGFLLFYL 337
            |..||::..||..|.|:.:..||.|||. ..||:. ..|.::|||:|:|||.|||......|.::
Zfish   237 GEHLSWLCLFWMLGGLYASFTAWGIIPHYGWGFSMGTEFQFHSWRVFVLVCFLPSVAALAGLVFM 301

  Fly   338 PESPKFLLTRGKKDRALAIFRGIFVTN--TKRRPDE-YMVYDLEV----DEKLLESNGNVKNKYS 395
            ||||:|||...:.|.|..|.|.:..||  .|..|:. :.|..::.    |::.:|........:.
Zfish   302 PESPRFLLESARHDEAWMILRRVHDTNWGAKGEPERVFQVSQIKTPQTQDDEFIEIQSETGTAFQ 366

  Fly   396 RMISGMVDHSRALFK------SPILRFTIVSITIN-FTFHIGYYGLLMWFPE--LFNRFEEYEK- 450
            |.:...:...:.:.|      :|.:|...:.|.|. ||....||||..|||:  .:.:|||||.
Zfish   367 RFMVRQMTLVKQVMKNMLSLAAPDVRLHGLFIAIVWFTMAFSYYGLGTWFPDQIKYLQFEEYESN 431

  Fly   451 -----------------------------------------AFPDQSAGVCAVTD---------- 464
                                                     .|.|.....|...|
Zfish   432 VKIFHRERVERFHFNFTLQNQLHKEGEYVHDRFINIEIRNVKFEDSLFENCYFEDIKSTETFFEN 496

  Fly   465 --------YVVNLAKEQS------NNGT-------CSSDIPQS----VFMESLISLASALPANLL 504
                    |..:|.::..      .|.|       |..:..:.    ::::|.:...|.:|.|:|
Zfish   497 CTLKNTVFYNTDLWEDSKFINCNLENTTFLHPKKGCHLNFQEENDILIYLDSFLGSLSVIPGNIL 561

  Fly   505 AILGMDMLGRKFFLIAGTMT-AGICSALMYFVRSSVQNLVVSAIFSGAISAANAALDCLITEVFP 568
            |.|.||.:|| ..:|.|:|. :.:|:..:....|....::...:|..|.:||...::.:..|::|
Zfish   562 AGLLMDKIGR-LKIIGGSMLGSAVCTFFLLLCFSQWAVVLFQCLFFAAGAAAWNGIEVVTVELYP 625

  Fly   569 TKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLPNT 626
            ...|||...:.....:|..||.:.:..:.:......|..:....|:.|||:...||.|
Zfish   626 ASKRATAFGVLNGTCKLAAIISSFIFGKFIGITKIIPIILSFSALVCGGLLAFKLPET 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	152/544 (28%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	155/564 (27%)
sv2ba	NP_001076464.1	synapt_SV2	36..689	CDD:130366	181/658 (28%)
sv2ba	NP_001076464.1	MFS	116..678	CDD:119392	155/562 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59613
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	1	1.000	-	-		FOG0001322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102121
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X658
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830