DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14440 and IKZF3

DIOPT Version :10

Sequence 1:NP_572343.1 Gene:CG14440 / 31610 FlyBaseID:FBgn0029894 Length:318 Species:Drosophila melanogaster
Sequence 2:NP_036613.2 Gene:IKZF3 / 22806 HGNCID:13178 Length:509 Species:Homo sapiens


Alignment Length:289 Identity:53/289 - (18%)
Similarity:104/289 - (35%) Gaps:84/289 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLGGILFATSSIGLLLNL--------LVVSPVFQLAFAKDKSSIYVISSVNIINDILHLLITTFY 65
            |:..:||   .|.||..|        :..||:|...:.    .::|::.|.|...::.:.::...
Human    48 LIPNVLF---FIFLLWKLPLARAKIRVTSSPIFITFYI----LVFVVALVGIARAVVSMTVSASD 105

  Fly    66 LAPTIILNSFIFSDERNGNLTVFISFIFMVLWYIGNITQIVMAVNRWAVICI------LRSSMFT 124
            .|..        :|:              :||   .||:..:.....:||.:      |.|....
Human   106 AATV--------ADK--------------ILW---EITRFFLLAIELSVIILGLAFGHLESKSSI 145

  Fly   125 KRNLIICFSFTLVFAVAKSYIVQYVFPCCSFLVDQTVLSYSYFQIENITNYTDHSDIPLNALSSI 189
            ||.|.|....:|.::|.:. .::.::|            .|:...|:...| .|.......:|| 
Human   146 KRVLAITTVLSLAYSVTQG-TLEILYP------------DSHLSAEDFNIY-GHGGRQFWLVSS- 195

  Fly   190 VPVICYSWIFYTIRSAHKSITPNMAPEHQKRQGRQELSYAMQFCLISMFYTFSWIMFRVFPIIFV 254
                |:.::.|::    ..|.|       |...::.:|...:    ..||.::.|:..:..:..:
Human   196 ----CFFFLVYSL----VVILP-------KTPLKERVSLPSR----RSFYVYAGILATLNLLQGL 241

  Fly   255 GRHIEWF-ILTSMCHVFNCSANAFVYILF 282
            |..:... |:..:|.|   .|..|:|..|
Human   242 GSALLCANIIVGLCCV---DATTFLYFSF 267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14440NP_572343.1 Smc <189..>303 CDD:440809 17/95 (18%)
IKZF3NP_036613.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..86 10/44 (23%)
C2H2 Zn finger 120..140 CDD:275368 2/19 (11%)
zf-H2C2_2 133..157 CDD:463886 6/23 (26%)
C2H2 Zn finger 148..168 CDD:275368 4/20 (20%)
zf-H2C2_2 160..183 CDD:463886 4/35 (11%)
C2H2 Zn finger 176..196 CDD:275368 5/25 (20%)
zf-H2C2_2 192..213 CDD:463886 7/36 (19%)
C2H2 Zn finger 204..220 CDD:275368 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..394
Mediates homodimerization and heterodimerization. /evidence=ECO:0000269|PubMed:34155405 452..504
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.