Protein Alignment CG14440 and IKZF1

DIOPT Version :10

• Sequence 1: NP_572343.1
• Gene: CG14440 / 31610
• FlyBaseID: FBgn0029894
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: XP_011513360.1
• Gene: IKZF1 / 10320
• HGNCID: 13176
• Length: 563
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 41/226 - (18%)
• Similarity: 81/226 - (35%)
• Gaps: 40/226 - (17%)

  Fly   110 GSASGTAVLSLENNFAQQGN--PHQQQQQQQQQGNPHQEVLQQQQQQHPLHHHLSAGVVVEASQL 172
            ||.....:..|.:|.|::.:  |.:....:.....|:......:::...:..|:....:..|...
Human   301 GSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINY 365

  Fly   173 GGVPGLANL---------GVPHLSAQQSVTQQGQSSRAQKAARRRSNESIEARERRLERNAARMR 228
            .|...|..|         .||.:|...      |..:.......|||.|  |::..:| |...:.
Human   366 LGAESLRPLVQTPPGGSEVVPVISPMY------QLHKPLAEGTPRSNHS--AQDSAVE-NLLLLS 421

  Fly   229 DKRAKESEAEYRVRLAKNAEANRVRRQNETEVQRT----------------LRLM-KNAARQRLR 276
            ..:...||.|   ....|:..:....::..|.||:                |.|. ::.|...||
Human   422 KAKLVPSERE---ASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLR 483

  Fly   277 RASETVEERKKRLAKAAERMRIARASAPKVI 307
            .|||..::..:.::.:.|:|::.:....:|:
Human   484 AASENSQDALRVVSTSGEQMKVYKCEHCRVL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14440	NP_572343.1	Smc	<189..>303	CDD:440809	25/130 (19%)
IKZF1	XP_011513360.1	C2H2 Zn finger	163..183	CDD:275368
		zf-H2C2_2	176..200	CDD:463886
		COG5048	187..>343	CDD:227381	7/41 (17%)
		C2H2 Zn finger	191..211	CDD:275368
		zf-H2C2_2	203..228	CDD:463886
		C2H2 Zn finger	219..239	CDD:275368
		zf-H2C2_2	235..256	CDD:463886
		C2H2 Zn finger	247..268	CDD:275368