Protein Alignment CG14442 and ZNF382

DIOPT Version :10

• Sequence 1: NP_572342.1
• Gene: CG14442 / 31609
• FlyBaseID: FBgn0029893
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_116214.2
• Gene: ZNF382 / 84911
• HGNCID: 17409
• Length: 550
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 53/268 - (19%)
• Similarity: 87/268 - (32%)
• Gaps: 67/268 - (25%)

  Fly    85 HLHQQQQDQLQFQQQHLQLYAPLKQQQLQQQQSQQPPTPLGPTSSASSASITG---ASTTGHQQ- 145
            :||:|.:..|..           ||:.:|.|:.|.|..|........|..:.|   ..|..|:.
Human   184 NLHKQTERVLSG-----------KQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGE 237

  Fly   146 ---RWNESPEA--RQRRLARNAERMRERRQRESEEEYRKRLLRN-AEANRQRRQNESDIERAMRL 204
               .:|:...|  .:..|:.:...:.|::. .:..:|.|.|.|. .....||.|.|
Human   238 RTFEYNKDGIAFIEKSSLSVHPSNLMEKKP-SAYNKYGKFLCRKPVFIMPQRPQTE--------- 292

  Fly   205 VRNAARQRLRRAMESP------DQRAKRLAKLAERMRMYRASETNDQRKLRLAEMAARA-RQRIA 262
                         |.|      ....:|.:.|.|..|::..      .|..:.....:| ||:.|
Human   293 -------------EKPFHCPYCGNNFRRKSYLIEHQRIHTG------EKPYVCNQCGKAFRQKTA 338

  Fly   263 ----NESPEERKERLRKLNDYAKKVREKKKVLKHVVVHGGSSSVVV----STPTSSSSSTDQQHH 319
                .::..|.|..:  ..|..|..|:|..:.:|...|.|..:...    |.....|...|.|..
Human   339 LTLHEKTHIEGKPFI--CIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRT 401

  Fly   320 HQQQQQQQ 327
            |..::..|
Human   402 HTGEKPYQ 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14442	NP_572342.1	PRK12705	153..>282	CDD:237178	25/142 (18%)
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		Represses transcription. /evidence=ECO:0000250	70..211		10/37 (27%)
		C2H2 Zn finger	214..234	CDD:275368	3/19 (16%)
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		24/122 (20%)
		C2H2 Zn finger	298..318	CDD:275368	4/19 (21%)
		zf-H2C2_2	310..335	CDD:463886	5/30 (17%)
		C2H2 Zn finger	326..346	CDD:275368	4/19 (21%)
		COG5048	<354..533	CDD:227381	13/56 (23%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		C2H2 Zn finger	382..402	CDD:275368	4/19 (21%)
		C2H2 Zn finger	410..430	CDD:275368	53/268 (20%)
		C2H2 Zn finger	438..458	CDD:275368
		C2H2 Zn finger	466..486	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	522..542	CDD:275368