DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14442 and ZNF382

DIOPT Version :9

Sequence 1:	NP_572342.1	Gene:	CG14442 / 31609	FlyBaseID:	FBgn0029893	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_116214.2	Gene:	ZNF382 / 84911	HGNCID:	17409	Length:	550	Species:	Homo sapiens

Alignment Length:	268	Identity:	53/268 - (19%)
Similarity:	87/268 - (32%)	Gaps:	67/268 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 HLHQQQQDQLQFQQQHLQLYAPLKQQQLQQQQSQQPPTPLGPTSSASSASITG---ASTTGHQQ- 145
            :||:|.:..|..           ||:.:|.|:.|.|..|........|..:.|   ..|..|:.
Human   184 NLHKQTERVLSG-----------KQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGE 237

  Fly   146 ---RWNESPEA--RQRRLARNAERMRERRQRESEEEYRKRLLRN-AEANRQRRQNESDIERAMRL 204
               .:|:...|  .:..|:.:...:.|::. .:..:|.|.|.|. .....||.|.|
Human   238 RTFEYNKDGIAFIEKSSLSVHPSNLMEKKP-SAYNKYGKFLCRKPVFIMPQRPQTE--------- 292

  Fly   205 VRNAARQRLRRAMESP------DQRAKRLAKLAERMRMYRASETNDQRKLRLAEMAARA-RQRIA 262
                         |.|      ....:|.:.|.|..|::..      .|..:.....:| ||:.|
Human   293 -------------EKPFHCPYCGNNFRRKSYLIEHQRIHTG------EKPYVCNQCGKAFRQKTA 338

  Fly   263 ----NESPEERKERLRKLNDYAKKVREKKKVLKHVVVHGGSSSVVV----STPTSSSSSTDQQHH 319
                .::..|.|..:  ..|..|..|:|..:.:|...|.|..:...    |.....|...|.|..
Human   339 LTLHEKTHIEGKPFI--CIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRT 401

  Fly   320 HQQQQQQQ 327
            |..::..|
Human   402 HTGEKPYQ 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14442	NP_572342.1	PRK11675	<692..>709	CDD:183272
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		Represses transcription. /evidence=ECO:0000250	70..211		10/37 (27%)
		C2H2 Zn finger	214..234	CDD:275368	3/19 (16%)
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		24/122 (20%)
		C2H2 Zn finger	298..318	CDD:275368	4/19 (21%)
		zf-H2C2_2	310..335	CDD:290200	5/30 (17%)
		C2H2 Zn finger	326..346	CDD:275368	4/19 (21%)
		COG5048	<354..533	CDD:227381	13/56 (23%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..389	CDD:290200	4/21 (19%)
		C2H2 Zn finger	382..402	CDD:275368	4/19 (21%)
		zf-H2C2_2	394..419	CDD:290200	4/16 (25%)
		C2H2 Zn finger	410..430	CDD:275368	53/268 (20%)
		zf-H2C2_2	423..445	CDD:290200
		C2H2 Zn finger	438..458	CDD:275368
		zf-H2C2_2	451..475	CDD:290200
		C2H2 Zn finger	466..486	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		zf-C2H2	494..514	CDD:278523
		zf-H2C2_2	506..531	CDD:290200
		C2H2 Zn finger	522..542	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930