DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14442 and ZNF639

DIOPT Version :9

Sequence 1:	NP_572342.1	Gene:	CG14442 / 31609	FlyBaseID:	FBgn0029893	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001290354.1	Gene:	ZNF639 / 51193	HGNCID:	30950	Length:	485	Species:	Homo sapiens

Alignment Length:	297	Identity:	55/297 - (18%)
Similarity:	94/297 - (31%)	Gaps:	94/297 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 QASQQHHQELSQIHVHSTADGDSRTPVLTPRRSGANKY--------------ETEEEKRIRLDKM 788
            ::..|..||.|.|.||:..|    .|:.....:.:..|              :|:||...:|.|:
Human   118 ESVNQQTQEESPIEVHTAED----VPIAVEVHAISEDYDIETENNSSESLQDQTDEEPPAKLCKI 178

  Fly   789 AAHQRAVRANETPEQRATRLQKLSER--------------ARLKRAQIRATENTDERKERLSKQA 839
            ....:|:  |.|.:|:...|:..|..              :.||:..|...:.||....|:.|::
Human   179 LDKSQAL--NVTAQQKWPLLRANSSGLYKCELCEFNSKYFSDLKQHMILKHKRTDSNVCRVCKES 241

  Fly   840 EYARMRRMRSHTPRSSSATSTEFRAKTEEEDE--CQ---------------DDDTSAEHHMYESE 887
            ....|..:.              .||..|||.  |:               ..||....|:|..|
Human   242 FSTNMLLIE--------------HAKLHEEDPYICKYCDYKTVIFENLSQHIADTHFSDHLYWCE 292

  Fly   888 AVSVTGTGSDGGFVSVVKADNDDSPLGGGDGSNDHEQLPALQLQQHELQQIAGSLQQQHLVPHPH 952
            ...|..:.|...::...:...|:..|              .|..:||...           |...
Human   293 QCDVQFSSSSELYLHFQEHSCDEQYL--------------CQFCEHETND-----------PEDL 332

  Fly   953 HEAIVLNQQHRLVTISQHQQQQLHQQQHPGFSKLQTV 989
            |..:|.....:|:.:|    .:.:..:|..:|.|..:
Human   333 HSHVVNEHACKLIELS----DKYNNGEHGQYSLLSKI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14442	NP_572342.1	PRK11675	<692..>709	CDD:183272
ZNF639	NP_001290354.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		C2H2 Zn finger	235..255	CDD:275368	5/33 (15%)
		C2H2 Zn finger	262..283	CDD:275368	2/20 (10%)
		C2H2 Zn finger	291..307	CDD:275368	3/15 (20%)
		Interaction with CTNNA2. /evidence=ECO:0000269\|PubMed:16182284	371..455
		C2H2 Zn finger	376..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930