DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14442 and Zfp382

DIOPT Version :9

Sequence 1:	NP_572342.1	Gene:	CG14442 / 31609	FlyBaseID:	FBgn0029893	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001380612.1	Gene:	Zfp382 / 246264	RGDID:	708385	Length:	567	Species:	Rattus norvegicus

Alignment Length:	176	Identity:	38/176 - (21%)
Similarity:	67/176 - (38%)	Gaps:	36/176 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   818 KRAQIRATENTDER-KERLSKQAEYAR----MRRMRSHTPRSSSATSTEFRAKTEEEDECQDDDT 877
            |...||..|..:|. .||:.....|..    :.:.|.:..:..::.......|..:|.....:.|
  Rat    57 KPDMIRKLEQGEELWTERMFPSQSYLEDEEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEKT 121

  Fly   878 SAEHHM-------YESEAVSVTGTGSDGGFVSVVKADNDDSPLGG--GDGSNDHEQLPALQLQQH 933
            ...:|:       |:|:. .|....||  |:|     .|.:|:.|  ||.|...|.:
  Rat   122 LGNNHIISKTLFEYKSDG-KVLKNISD--FIS-----RDINPVMGTLGDSSEWEESV-------- 170

  Fly   934 ELQQIAGSLQQQHLVPHPHHEAIVLNQQHRLVTISQHQQQQLHQQQ 979
                :....::.|.|| ..::.|..|....| .::|||:.|:.:|:
  Rat   171 ----LTSEQEKTHPVP-TLYKQIGRNLSSSL-ELAQHQKTQIPEQR 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14442	NP_572342.1	PRK11675	<692..>709	CDD:183272
Zfp382	NP_001380612.1	Mediates interaction with TRIM28. /evidence=ECO:0000269\|PubMed:11154279	1..105		9/47 (19%)
		Represses transcription	10..51
		KRAB	12..72	CDD:214630	5/14 (36%)
		Represses transcription	75..210		30/156 (19%)
		C2H2 Zn finger	273..289	CDD:275368
		COG5048	<293..532	CDD:227381
		C2H2 Zn finger	297..317	CDD:275368
		C2H2 Zn finger	325..345	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
		C2H2 Zn finger	381..401	CDD:275368
		C2H2 Zn finger	409..429	CDD:275368
		C2H2 Zn finger	437..457	CDD:275368
		C2H2 Zn finger	465..485	CDD:275368
		C2H2 Zn finger	493..513	CDD:275368
		C2H2 Zn finger	521..541	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930