DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14442 and IKZF1

DIOPT Version :9

Sequence 1:	NP_572342.1	Gene:	CG14442 / 31609	FlyBaseID:	FBgn0029893	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_011513360.1	Gene:	IKZF1 / 10320	HGNCID:	13176	Length:	563	Species:	Homo sapiens

Alignment Length:	285	Identity:	51/285 - (17%)
Similarity:	97/285 - (34%)	Gaps:	84/285 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   733 GRPLSQ-ASQQHHQELSQIHVHSTADGDSRTPVLTPRRSGANKYETEE-------EKRIRLDKMA 789
            ||...| :|.:.|:|....::.|.....:..||:   :...|..|..|       |:.:.||::|
Human   251 GRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI---KEETNHSEMAEDLCKIGSERSLVLDRLA 312

  Fly   790 AHQRAVRA------------NETPEQRATRLQKLSER------------------ARLKRAQIRA 824
            ::....::            ::||...:...:|.:|.                  |...|..::.
Human   313 SNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQT 377

  Fly   825 TENTDERKERLSKQAEYARMRRMRSHTPRSSSATSTEFRAKTEEEDECQDDDTSAEHHMYESEAV 889
            .....|....:|..  |...:.:...||||:.:.                .|::.|:.:..|:|
Human   378 PPGGSEVVPVISPM--YQLHKPLAEGTPRSNHSA----------------QDSAVENLLLLSKA- 423

  Fly   890 SVTGTGSDGGFVSVVKADNDDSPLGGGDGSNDHEQLPALQLQQHELQQIAGSLQQQHLVPHPHHE 954
                        .:|.::.:.||......|.|.|       ..:|.|:........|:.||..:
Human   424 ------------KLVPSEREASPSNSCQDSTDTE-------SNNEEQRSGLIYLTNHIAPHARN- 468

  Fly   955 AIVLNQQHR----LVTISQHQQQQL 975
            .:.|.::||    |...|::.|..|
Human   469 GLSLKEEHRAYDLLRAASENSQDAL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14442	NP_572342.1	PRK11675	<692..>709	CDD:183272
IKZF1	XP_011513360.1	C2H2 Zn finger	163..183	CDD:275368
		zf-H2C2_2	176..200	CDD:372612
		COG5048	187..>343	CDD:227381	18/94 (19%)
		C2H2 Zn finger	191..211	CDD:275368
		zf-H2C2_2	203..228	CDD:372612
		C2H2 Zn finger	219..239	CDD:275368
		C2H2 Zn finger	247..268	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930