DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3184 and RRT2

DIOPT Version :9

Sequence 1:	NP_572341.1	Gene:	CG3184 / 31608	FlyBaseID:	FBgn0029892	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_009805.1	Gene:	RRT2 / 852548	SGDID:	S000000450	Length:	387	Species:	Saccharomyces cerevisiae

Alignment Length:	346	Identity:	97/346 - (28%)
Similarity:	146/346 - (42%)	Gaps:	89/346 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RLQCIETS--AILDMKWLP----------------AWSSEC------NPHLATVNSLGQMELYEF 112
            :|.|...:  ||||:|..|                .|...|      ..:...::::..::|:|.
Yeast    56 KLLCSNNTYGAILDLKLSPFDDTLICTAHSTGNIMLWRIRCTDKDDFQSNELDIHAIANLQLFEK 120

  Fly   113 -----------LQDAKLLQRRTCFSLAEQDSSEEAPLALALDWQHDGQHIRLAISDSKGGLNLLS 166
                       |...|||...|....|..|..     .|::      |....||:.:...|:.:.
Yeast   121 DVLIASCHFSPLDCKKLLVTNTAGEAATIDIR-----TLSV------QFTASAIAQAYSKLDKID 174

  Fly   167 YSSQG---EIIRERS--WLS-HGFEAWTCAFDRWSP--HILYSGGDDMLLMAHDLRTKQRAWT-N 222
            |..||   ::|...|  :|. |..|.||..|....|  .::::||||..:||||||:|:..|: |
Yeast   175 YEVQGATEKVIHVESGQFLKPHELECWTAEFGSLQPFQDVVFTGGDDSRIMAHDLRSKEFIWSNN 239

  Fly   223 RAHMAGVTCL-LSHPRHENH----LLTGSYDEQLRLFDTRSMKRSL-----------AELDLSGG 271
            |.|.|||..: .|.|...|:    ::|||||:.:|..|.|.|..|:           ...||.||
Yeast   240 RIHDAGVVSIKCSQPNFRNNKPTSIITGSYDDNIRSLDLRMMGESIFPGANVPTVNKLACDLGGG 304

  Fly   272 IWRL--------KPHPAQPDLILAACMYTNFSVVQLDVAAPGLSLLGAY--EEHKSICYGADWAP 326
            :||.        :.|....|.:|..|||....||.::..:.....:..|  :.|.|:|||.||
Yeast   305 VWRFVESPIDQEQSHHNGSDRLLVCCMYNGAKVVTMNDNSDEYFQIQHYLKKGHDSMCYGGDW-- 367

  Fly   327 WRNKDDASLTMATCSFYDHTL 347
                  ::..:|||||||::|
Yeast   368 ------SNSLIATCSFYDNSL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3184	NP_572341.1	WD40	92..>267	CDD:225201	58/216 (27%)
		WD40 repeat	141..181	CDD:293791	9/44 (20%)
		WD40	<169..349	CDD:295369	72/214 (34%)
		WD40 repeat	187..222	CDD:293791	16/37 (43%)
		WD40 repeat	229..267	CDD:293791	14/53 (26%)
		WD40 repeat	272..313	CDD:293791	11/50 (22%)
		WD40 repeat	319..349	CDD:293791	13/29 (45%)
RRT2	NP_009805.1	WD40	65..>130	CDD:421866	10/64 (16%)
		WD40 repeat	68..117	CDD:293791	6/48 (13%)
		WD40 repeat	122..194	CDD:293791	17/82 (21%)
		WD40 repeat	201..239	CDD:293791	16/37 (43%)
		WD40 repeat	246..298	CDD:293791	14/51 (27%)
		WD40 repeat	305..355	CDD:293791	11/49 (22%)
		WD40 repeat	362..385	CDD:293791	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I1461
eggNOG	1	0.900	-	-		E1_KOG0280
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I1410
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54672
OrthoFinder	1	1.000	-	-		FOG0005135
OrthoInspector	1	1.000	-	-		oto100354
orthoMCL	1	0.900	-	-		OOG6_103086
Panther	1	1.100	-	-	LDO	PTHR46042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1670
SonicParanoid	1	1.000	-	-		X3653
TreeFam	1	0.960	-	-
	13	12.860