DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum2 and FUM1

DIOPT Version :9

Sequence 1:	NP_727109.2	Gene:	Fum2 / 31606	FlyBaseID:	FBgn0029890	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_015061.1	Gene:	FUM1 / 855866	SGDID:	S000006183	Length:	488	Species:	Saccharomyces cerevisiae

Alignment Length:	490	Identity:	293/490 - (59%)
Similarity:	370/490 - (75%)	Gaps:	11/490 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LRAKDCD------SGGKGGKGKENGKFRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERM 80
            ||..:|.      |..|....:.|..||||.|.|||:.|||||.:||||.||..||.||...|||
Yeast     2 LRFTNCSCKTFVKSSYKLNIRRMNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERM 66

  Fly    81 PMPVIQAMGILKKACAEVNKDY-GLDGKVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTN 144
            |:|::.|.|:|||:.|.||:.. |||.|:|.|:..|.|:|.||||  ..|||||::|||||||:|
Yeast    67 PLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEVASGKL--DDHFPLVVFQTGSGTQSN 129

  Fly   145 MNTNEVISNAAIKMMGGELGSKKPVHPNDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLR 209
            ||.||||||.||:::||::|||: ||||:|.|:||||||||||.:||:..:::...|:|.:|:|:
Yeast   130 MNANEVISNRAIEILGGKIGSKQ-VHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLK 193

  Fly   210 DALKSKSDEFKDIIKIGRTHLMDAVPLTLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVG 274
            :||::||.||..|:|||||||.||.|||||||||||.||:.||::|:...|..:..||.||||||
Yeast   194 NALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVG 258

  Fly   275 TGLNTRKGFAEKVAKRISELTCLPFVSAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLL 339
            |||||:.||..|:|::||:.|.|.|.:||||||||||.||:||..|.|||:|.||.|||.|||.|
Yeast   259 TGLNTKPGFDVKIAEQISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYL 323

  Fly   340 GSGPRCGLGELMLPENEPGSSIMPGKVNPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKP 404
            |||||||..||||||||||||||||||||||.|::|.:|.|||||..|:|..||.|.||||||||
Yeast   324 GSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKP 388

  Fly   405 LVVSNVLRSIRLLADGSMTFSKNCVEGLQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTA 469
            ::::|:|.||||:.|.:.:|..:||||::||:.||.:::.:||||||||||.||||.|:.:||.|
Yeast   389 VMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNA 453

  Fly   470 HKNKTTLKEEALKTGI-TEEQFKEWVNPKEMLGPK 503
            ||...||||.||:.|: ||::|.|||.|:.|||||
Yeast   454 HKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum2	NP_727109.2	fumC	42..503	CDD:234779	285/462 (62%)
Fum2	NP_727109.2	Fumarase_classII	43..499	CDD:176465	281/457 (61%)
FUM1	NP_015061.1	fumC	26..488	CDD:234779	285/464 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346588
Domainoid	1	1.000	427	1.000	Domainoid score	I71
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	590	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61095
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm46567
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
TreeFam	1	0.960	-	-
	13	12.760