DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum2 and FUM2

DIOPT Version :9

Sequence 1:	NP_727109.2	Gene:	Fum2 / 31606	FlyBaseID:	FBgn0029890	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_851166.1	Gene:	FUM2 / 835168	AraportID:	AT5G50950	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	453	Identity:	293/453 - (64%)
Similarity:	355/453 - (78%)	Gaps:	6/453 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLDG 106
            ||.|:||||.::||:|||:||||.||..||.||...||||.|:::|.|:|||..|:||.:||||.
plant    39 FREERDTFGPIQVPSDKLWGAQTQRSLQNFEIGGDRERMPEPIVRAFGVLKKCAAKVNMEYGLDP 103

  Fly   107 KVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHP 171
            .:.:|:..|..:|..|||  ..|||||:||||||||:|||.||||:|.|.:::|.:.| :|.|||
plant   104 MIGEAIMEAAQEVAEGKL--NDHFPLVVWQTGSGTQSNMNANEVIANRAAEILGHKRG-EKIVHP 165

  Fly   172 NDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPL 236
            |||||:||||||||||.:||:...|:..||:|::.:|..:|:|||.|||||:||||||..||.||
plant   166 NDHVNRSQSSNDTFPTVMHIAAATEITSRLIPSLKNLHSSLESKSFEFKDIVKIGRTHTQDATPL 230

  Fly   237 TLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFVS 301
            ||||||.||..|:..||.|:...|||:|:||.|||||||||||:|||..|:|..::|.|.||||:
plant   231 TLGQEFGGYATQVEYGLNRVACTLPRIYQLAQGGTAVGTGLNTKKGFDVKIAAAVAEETNLPFVT 295

  Fly   302 APNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKV 366
            |.||||||||.||.||..|.|||||.||||||||||.||||||||||||.|||||||||||||||
plant   296 AENKFEALAAHDACVETSGSLNTIATSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKV 360

  Fly   367 NPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEG 431
            ||||||::||:|||||||.|||||||||||||||||||::.|.:|.||||:||.|.:|.||||.|
plant   361 NPTQCEALTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIASALLHSIRLIADASASFEKNCVRG 425

  Fly   432 LQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLK-EEALKT--GITEEQFK 491
            ::||:|||.|:::|||||||:|||.||||.||.:||.|||...||| ...|.|  .:.:.:||
plant   426 IEANRERISKLLHESLMLVTSLNPKIGYDNAAAVAKRAHKEGCTLKVNNKLLTFSSLNKSEFK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum2	NP_727109.2	fumC	42..503	CDD:234779	293/453 (65%)
Fum2	NP_727109.2	Fumarase_classII	43..499	CDD:176465	292/452 (65%)
FUM2	NP_851166.1	Fumarase_classII	40..471	CDD:176465	286/433 (66%)
FUM2	NP_851166.1	PLN00134	46..503	CDD:215069	288/446 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	468	1.000	Domainoid score	I90
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	648	1.000	Inparanoid score	I173
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		mtm1198
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840