DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum2 and fh

DIOPT Version :9

Sequence 1:	NP_727109.2	Gene:	Fum2 / 31606	FlyBaseID:	FBgn0029890	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_957257.1	Gene:	fh / 393938	ZFINID:	ZDB-GENE-010724-6	Length:	509	Species:	Danio rerio

Alignment Length:	463	Identity:	337/463 - (72%)
Similarity:	394/463 - (85%)	Gaps:	3/463 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLDG 106
            ||.|:|||||||||:||.|||||:||.:||.||.:.||||:.||:|.||||||.||||||||||.
Zfish    49 FRIERDTFGELKVPSDKYYGAQTVRSTMNFRIGGVTERMPIQVIRAFGILKKAAAEVNKDYGLDP 113

  Fly   107 KVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHP 171
            |::||:..|.|:|.||||  ..|||||:||||||||||||.||||||.||:|:||:||||.||||
Zfish   114 KIADAIMKAADEVESGKL--DDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGKLGSKDPVHP 176

  Fly   172 NDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPL 236
            |||||||||||||||||:||:...|::|.|:|.:..|.|||.:|:::|||||||||||..|||||
Zfish   177 NDHVNKSQSSNDTFPTAMHIAAAKEVHEVLLPGLQTLHDALAAKAEQFKDIIKIGRTHTQDAVPL 241

  Fly   237 TLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFVS 301
            :|||||.||.||:...:.|:|..||||||||.||||||||||||.|||||||.::|.||.||||:
Zfish   242 SLGQEFGGYVQQVKYSIARVKASLPRVYELAAGGTAVGTGLNTRIGFAEKVADKVSALTGLPFVT 306

  Fly   302 APNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKV 366
            |.||||||||.||:||:.|.|||:|||:||||||||.||||||.|||||:|||||||||||||||
Zfish   307 AANKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKV 371

  Fly   367 NPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEG 431
            ||||||:|||:.||||||.||||:||||||||||||||:::.|||.|.|||.|.|::|:.|||.|
Zfish   372 NPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMIIKNVLNSARLLGDASVSFTNNCVVG 436

  Fly   432 LQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTG-ITEEQFKEWVN 495
            ::||.|||:|:|:|||||||||||||||||||.|||||||:.:||||.|||.| :.|:||:|||.
Zfish   437 IEANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKDGSTLKEAALKLGFLNEQQFEEWVR 501

  Fly   496 PKEMLGPK 503
            |.:|||||
Zfish   502 PHDMLGPK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum2	NP_727109.2	fumC	42..503	CDD:234779	335/461 (73%)
Fum2	NP_727109.2	Fumarase_classII	43..499	CDD:176465	331/456 (73%)
fh	NP_957257.1	fumC	46..509	CDD:234779	335/461 (73%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	144..146		1/1 (100%)
		Substrate binding (B site). /evidence=ECO:0000250\|UniProtKB:P05042	175..178		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	185..187		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P9WN93	370..372		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596184
Domainoid	1	1.000	522	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	721	1.000	Inparanoid score	I616
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm25446
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770