DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fum2 and FH

DIOPT Version :9

Sequence 1:NP_727109.2 Gene:Fum2 / 31606 FlyBaseID:FBgn0029890 Length:503 Species:Drosophila melanogaster
Sequence 2:NP_000134.2 Gene:FH / 2271 HGNCID:3700 Length:510 Species:Homo sapiens


Alignment Length:463 Identity:338/463 - (73%)
Similarity:390/463 - (84%) Gaps:3/463 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 FRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLDG 106
            ||.|.|||||||||.||.|||||:||.:||.||.:.||||.|||:|.||||:|.||||:|||||.
Human    50 FRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDP 114

  Fly   107 KVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHP 171
            |:::|:..|.|:|..|||  ..|||||:||||||||||||.||||||.||:|:|||||||.||||
Human   115 KIANAIMKAADEVAEGKL--NDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHP 177

  Fly   172 NDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPL 236
            |||||||||||||||||:||:..:|::|.|:|.:..|.|||.:||.||..||||||||..|||||
Human   178 NDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPL 242

  Fly   237 TLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFVS 301
            |||||||||.||:...:.|||..:||:||||.||||||||||||.|||||||.:::.||.||||:
Human   243 TLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVT 307

  Fly   302 APNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKV 366
            ||||||||||.||:||:.|.:||.|.||||||||||.||||||.|||||:|||||||||||||||
Human   308 APNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKV 372

  Fly   367 NPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEG 431
            ||||||:|||:.||||||.||||:||||||||||||||:::.|||.|.|||.|.|::|::|||.|
Human   373 NPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVG 437

  Fly   432 LQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTG-ITEEQFKEWVN 495
            :|||.|||:|:|||||||||||||||||||||.||||||||.:||||.|::.| :|.|||.|||.
Human   438 IQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVK 502

  Fly   496 PKEMLGPK 503
            ||:|||||
Human   503 PKDMLGPK 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fum2NP_727109.2 fumC 42..503 CDD:234779 336/461 (73%)
Fumarase_classII 43..499 CDD:176465 332/456 (73%)
FHNP_000134.2 fumC 49..510 CDD:234779 336/461 (73%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 145..147 1/1 (100%)
Substrate binding (B site). /evidence=ECO:0000250|UniProtKB:P05042 176..179 2/2 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 186..188 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P9WN93 371..373 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159913
Domainoid 1 1.000 520 1.000 Domainoid score I305
eggNOG 1 0.900 - - E1_COG0114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 725 1.000 Inparanoid score I621
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG61095
OrthoDB 1 1.010 - - D1022919at2759
OrthoFinder 1 1.000 - - FOG0002459
OrthoInspector 1 1.000 - - otm40526
orthoMCL 1 0.900 - - OOG6_101016
Panther 1 1.100 - - O PTHR11444
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1641
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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