DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum2 and fum-1

DIOPT Version :9

Sequence 1:	NP_727109.2	Gene:	Fum2 / 31606	FlyBaseID:	FBgn0029890	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_498642.1	Gene:	fum-1 / 176059	WormBaseID:	WBGene00001503	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	343/464 - (73%)
Similarity:	395/464 - (85%)	Gaps:	3/464 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KFRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLD 105
            |.|.|:||||||:|||||.|||||.||::||.||...||||:|||.|.||||||.|.||.::|||
Worm    40 KIRKERDTFGELEVPADKYYGAQTARSQMNFKIGGPEERMPIPVIHAFGILKKAAALVNTEFGLD 104

  Fly   106 GKVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVH 170
            .|::||:|.|.|:|:.|||  ..|||||.||||||||:|||.||||||.||:::|||||||||||
Worm   105 KKLADAISQAADEVVDGKL--DEHFPLVTWQTGSGTQSNMNVNEVISNRAIEILGGELGSKKPVH 167

  Fly   171 PNDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVP 235
            ||||||.|||||||||||:||:||.|:|.||:||:..||.||.:|::||||||||||||..||||
Worm   168 PNDHVNMSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVP 232

  Fly   236 LTLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFV 300
            ||||||||.|..||.|.:.|::..|||:|:||.||||||||||||||||||||..:||||.||||
Worm   233 LTLGQEFSAYVTQLDNSIARVESTLPRLYQLAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFV 297

  Fly   301 SAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGK 365
            :||||||||||.||:|||||.|||:|||.|||.||||.||||||||||||.||||||||||||||
Worm   298 TAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGK 362

  Fly   366 VNPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVE 430
            |||||||::||:.||||||||||::|||||||||||||||:|.|||:|.|||||.:::|:.:||:
Worm   363 VNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVD 427

  Fly   431 GLQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTGI-TEEQFKEWV 494
            |:.|||:.|.|||.||||||||||||||||.||.||||||||.|||.:||:|.|| |||||.:||
Worm   428 GIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWV 492

  Fly   495 NPKEMLGPK 503
            .|:.|||||
Worm   493 KPENMLGPK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum2	NP_727109.2	fumC	42..503	CDD:234779	340/461 (74%)
Fum2	NP_727109.2	Fumarase_classII	43..499	CDD:176465	337/456 (74%)
fum-1	NP_498642.1	fumC	38..501	CDD:234779	341/462 (74%)
fum-1	NP_498642.1	Fumarase_classII	42..497	CDD:176465	337/456 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167430
Domainoid	1	1.000	522	1.000	Domainoid score	I148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	722	1.000	Inparanoid score	I327
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm14286
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910