DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fum2 and Fh1

DIOPT Version :9

Sequence 1:NP_727109.2 Gene:Fum2 / 31606 FlyBaseID:FBgn0029890 Length:503 Species:Drosophila melanogaster
Sequence 2:NP_034339.2 Gene:Fh1 / 14194 MGIID:95530 Length:507 Species:Mus musculus


Alignment Length:463 Identity:337/463 - (72%)
Similarity:389/463 - (84%) Gaps:3/463 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 FRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLDG 106
            ||.|.|||||||||.||.|||||:||.:||.||...||||:|||||.||||:|.||||::||||.
Mouse    47 FRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYGLDP 111

  Fly   107 KVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHP 171
            |::.|:..|.|:|..|||  ..|||||:||||||||||||.||||||.||:|:||||||||||||
Mouse   112 KIASAIMKAADEVAEGKL--NDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHP 174

  Fly   172 NDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPL 236
            |||||||||||||||||:||:..:|:::.|:|.:..|.|||.:||.||..:|||||||..|||||
Mouse   175 NDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPL 239

  Fly   237 TLGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFVS 301
            |||||||||.||:...:.|||..:||:||||.||||||||||||.|||||||.:::.||.||||:
Mouse   240 TLGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVT 304

  Fly   302 APNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKV 366
            ||||||||||.||:||:.|.:||.|.||||||||||.||||||.|||||:|||||||||||||||
Mouse   305 APNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKV 369

  Fly   367 NPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEG 431
            ||||||:|||:.||||||.||||:||||||||||||||:::.|||.|.|||.|.|::|:.|||.|
Mouse   370 NPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVG 434

  Fly   432 LQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTG-ITEEQFKEWVN 495
            :|||.|||:|:|||||||||||||||||||||.||||||||.:||||.|::.| :|.|||.|||.
Mouse   435 IQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVK 499

  Fly   496 PKEMLGPK 503
            ||:|||||
Mouse   500 PKDMLGPK 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fum2NP_727109.2 fumC 42..503 CDD:234779 335/461 (73%)
Fumarase_classII 43..499 CDD:176465 331/456 (73%)
Fh1NP_034339.2 fumC 46..507 CDD:234779 335/461 (73%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 142..144 1/1 (100%)
Substrate binding (B site). /evidence=ECO:0000250|UniProtKB:P05042 173..176 2/2 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 183..185 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P9WN93 368..370 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850283
Domainoid 1 1.000 522 1.000 Domainoid score I300
eggNOG 1 0.900 - - E1_COG0114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 730 1.000 Inparanoid score I613
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG61095
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002459
OrthoInspector 1 1.000 - - otm42598
orthoMCL 1 0.900 - - OOG6_101016
Panther 1 1.100 - - O PTHR11444
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1641
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.760

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