DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum1 and FUM2

DIOPT Version :9

Sequence 1:	NP_572339.1	Gene:	Fum1 / 31605	FlyBaseID:	FBgn0286222	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_851166.1	Gene:	FUM2 / 835168	AraportID:	AT5G50950	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	456	Identity:	314/456 - (68%)
Similarity:	363/456 - (79%)	Gaps:	5/456 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLASQEFRVESDTFGELKVPADKYYGAQTMRSQINFPIGGATERMPKPVVQAMGILKKAAAEVNK 92
            |..|..||.|.||||.::||:||.:||||.||..||.|||..||||:|:|:|.|:|||.||:||.
plant    33 RSYSTPFREERDTFGPIQVPSDKLWGAQTQRSLQNFEIGGDRERMPEPIVRAFGVLKKCAAKVNM 97

  Fly    93 EFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGSGTQSNMNVNEVISNRAIELLGGKLGSK 157
            |:|||..:.|||.:||.:|..||| :||||||:||||||||||||.||||:|||.|:||.|.|.|
plant    98 EYGLDPMIGEAIMEAAQEVAEGKL-NDHFPLVVWQTGSGTQSNMNANEVIANRAAEILGHKRGEK 161

  Fly   158 TPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPAIKTLHDALRAKSEEFKDIIKIGRTHTM 222
            . ||||||||:||||||||||.:||:.|.|:.:.|.|::|.||.:|.:||.|||||:|||||||.
plant   162 I-VHPNDHVNRSQSSNDTFPTVMHIAAATEITSRLIPSLKNLHSSLESKSFEFKDIVKIGRTHTQ 225

  Fly   223 DAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAVGTGLNTRKGFAEKCAAKIAELTS 287
            ||.||||||||.|||.|:.|...|:...|||:|:||.|||||||||||:|||..|.||.:||.|:
plant   226 DATPLTLGQEFGGYATQVEYGLNRVACTLPRIYQLAQGGTAVGTGLNTKKGFDVKIAAAVAEETN 290

  Fly   288 LPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSI 352
            ||||||.||||||||.||.||..|.|||||.||||||||||||||||||||||||||||||||||
plant   291 LPFVTAENKFEALAAHDACVETSGSLNTIATSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSI 355

  Fly   353 MPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLSDGSRTFTA 417
            |||||||||||:|||:.||||||.|||||||||||||||||||:|.|.:|.||||::|.|.:|..
plant   356 MPGKVNPTQCEALTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIASALLHSIRLIADASASFEK 420

  Fly   418 NCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAKIAKTAHKNGTTLKEEAINLGYLTEQQF 482
            |||.||:||||.|:|:::|||||||:|||.||||.||.:||.|||.|.|||   :|...||....
plant   421 NCVRGIEANRERISKLLHESLMLVTSLNPKIGYDNAAAVAKRAHKEGCTLK---VNNKLLTFSSL 482

  Fly   483 N 483
            |
plant   483 N 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum1	NP_572339.1	fumC	31..495	CDD:234779	313/453 (69%)
FUM2	NP_851166.1	Fumarase_classII	40..471	CDD:176465	305/432 (71%)
FUM2	NP_851166.1	PLN00134	46..503	CDD:215069	307/443 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	468	1.000	Domainoid score	I90
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115
Inparanoid	1	1.050	648	1.000	Inparanoid score	I173
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		mtm1198
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840