DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fum1 and fh

DIOPT Version :9

Sequence 1:	NP_572339.1	Gene:	Fum1 / 31605	FlyBaseID:	FBgn0286222	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_957257.1	Gene:	fh / 393938	ZFINID:	ZDB-GENE-010724-6	Length:	509	Species:	Danio rerio

Alignment Length:	495	Identity:	366/495 - (73%)
Similarity:	419/495 - (84%)	Gaps:	9/495 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 STLRGVQQMTK-------PWAAIGSLRLASQE-FRVESDTFGELKVPADKYYGAQTMRSQINFPI 65
            |.||..|:..|       |.....::|:||.| ||:|.|||||||||:||||||||:||.:||.|
Zfish    16 SDLRAAQRSIKARNVCPAPGLRHQTVRMASSEAFRIERDTFGELKVPSDKYYGAQTVRSTMNFRI 80

  Fly    66 GGATERMPKPVVQAMGILKKAAAEVNKEFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGS 130
            ||.|||||..|::|.||||||||||||::|||.|:::||.||||:|.|||| |||||||:|||||
Zfish    81 GGVTERMPIQVIRAFGILKKAAAEVNKDYGLDPKIADAIMKAADEVESGKL-DDHFPLVVWQTGS 144

  Fly   131 GTQSNMNVNEVISNRAIELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPA 195
            |||:||||||||||||||:||||||||.|||||||||||||||||||||:||:.|.|::..|.|.
Zfish   145 GTQTNMNVNEVISNRAIEMLGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAAKEVHEVLLPG 209

  Fly   196 IKTLHDALRAKSEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALG 260
            ::||||||.||:|:||||||||||||.|||||:|||||.||.||:.|:..|:.|.||||||||.|
Zfish   210 LQTLHDALAAKAEQFKDIIKIGRTHTQDAVPLSLGQEFGGYVQQVKYSIARVKASLPRVYELAAG 274

  Fly   261 GTAVGTGLNTRKGFAEKCAAKIAELTSLPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIAN 325
            |||||||||||.|||||.|.|::.||.||||||.||||||||.||:||:.|.|||:|||:|||||
Zfish   275 GTAVGTGLNTRIGFAEKVADKVSALTGLPFVTAANKFEALAAHDALVELSGALNTVAVSMMKIAN 339

  Fly   326 DIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFEL 390
            ||||||||||.|||||.|||||||||||||||||||||::||::||||||.||||:|||||||||
Zfish   340 DIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFEL 404

  Fly   391 NVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAK 455
            |||||:|:.|||.|.|||.|.|.:||.|||.||:||.|.|.|:|:||||||||||||||||||||
Zfish   405 NVFKPMIIKNVLNSARLLGDASVSFTNNCVVGIEANTERINKLMSESLMLVTALNPHIGYDKAAK 469

  Fly   456 IAKTAHKNGTTLKEEAINLGYLTEQQFNDWVRPEQMLGPK 495
            |||||||:|:||||.|:.||:|.||||.:||||..|||||
Zfish   470 IAKTAHKDGSTLKEAALKLGFLNEQQFEEWVRPHDMLGPK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum1	NP_572339.1	fumC	31..495	CDD:234779	356/464 (77%)
fh	NP_957257.1	fumC	46..509	CDD:234779	355/463 (77%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	144..146		1/1 (100%)
		Substrate binding (B site). /evidence=ECO:0000250\|UniProtKB:P05042	175..178		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	185..187		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P9WN93	370..372		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596186
Domainoid	1	1.000	522	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115
Inparanoid	1	1.050	721	1.000	Inparanoid score	I616
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm25446
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	LDO	PTHR11444
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R461
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800