Protein Alignment Fum1 and FH

DIOPT Version :10

• Sequence 1: NP_572339.1
• Gene: Fum1 / 31605
• FlyBaseID: FBgn0286222
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_000134.2
• Gene: FH / 2271
• HGNCID: 3700
• Length: 510
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 369/511 - (72%)
• Similarity: 420/511 - (82%)
• Gaps: 23/511 - (4%)

  Fly     3 LPLLQRSTLRGVQQMTKPWAAIGS-----------------LRLASQ-EFRVESDTFGELKVPAD 49
            |.||.||.    ..:..|.||:.|                 .|:||| .||:|.|||||||||.|
Human     5 LRLLARSR----PLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGELKVPND 65

  Fly    50 KYYGAQTMRSQINFPIGGATERMPKPVVQAMGILKKAAAEVNKEFGLDSKVSEAISKAADDVISG 114
            |||||||:||.:||.|||.|||||.||::|.||||:||||||:::|||.|::.||.||||:|..|
Human    66 KYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEG 130

  Fly   115 KLYDDHFPLVIWQTGSGTQSNMNVNEVISNRAIELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTA 179
            || :||||||:||||||||:||||||||||||||:|||:||||.|||||||||||||||||||||
Human   131 KL-NDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTA 194

  Fly   180 IHISVALELNNNLKPAIKTLHDALRAKSEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQ 244
            :||:.|:|::..|.|.::.|||||.|||:||..|||||||||.||||||||||||||.||:.||.
Human   195 MHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAM 259

  Fly   245 ERIDACLPRVYELALGGTAVGTGLNTRKGFAEKCAAKIAELTSLPFVTAPNKFEALAARDAMVEV 309
            .||.|.:||:||||.||||||||||||.|||||.|||:|.||.|||||||||||||||.||:||:
Human   260 TRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVEL 324

  Fly   310 HGVLNTIAVSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMLSAQVMG 374
            .|.:||.|.|||||||||||||||||.|||||.|||||||||||||||||||||::||::|||||
Human   325 SGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMG 389

  Fly   375 NQVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLM 439
            |.||||:||||||||||||||:::.|||.|.|||.|.|.:||.|||.|||||.|.|.|:||||||
Human   390 NHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLM 454

  Fly   440 LVTALNPHIGYDKAAKIAKTAHKNGTTLKEEAINLGYLTEQQFNDWVRPEQMLGPK 495
            |||||||||||||||||||||||||:||||.||.|||||.:||::||:|:.|||||
Human   455 LVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fum1	NP_572339.1	FumC	31..493	CDD:439884	354/462 (77%)
FH	NP_000134.2	FumC	49..508	CDD:439884	352/459 (77%)