DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fum1 and fum-1

DIOPT Version :9

Sequence 1:	NP_572339.1	Gene:	Fum1 / 31605	FlyBaseID:	FBgn0286222	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_498642.1	Gene:	fum-1 / 176059	WormBaseID:	WBGene00001503	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	364/487 - (74%)
Similarity:	412/487 - (84%)	Gaps:	11/487 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 STLRGVQQMTKPWAAIGSLRLASQEFRVESDTFGELKVPADKYYGAQTMRSQINFPIGGATERMP 73
            :|.|...:.|.|.|.|          |.|.||||||:|||||||||||.|||:||.|||..||||
Worm    26 ATARNFSRTTVPMAKI----------RKERDTFGELEVPADKYYGAQTARSQMNFKIGGPEERMP 80

  Fly    74 KPVVQAMGILKKAAAEVNKEFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGSGTQSNMNV 138
            .||:.|.||||||||.||.|||||.|:::|||:|||:|:.||| |:|||||.|||||||||||||
Worm    81 IPVIHAFGILKKAAALVNTEFGLDKKLADAISQAADEVVDGKL-DEHFPLVTWQTGSGTQSNMNV 144

  Fly   139 NEVISNRAIELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPAIKTLHDAL 203
            ||||||||||:|||:||||.|||||||||.|||||||||||:||:|..|:|:.|.||:|.|..||
Worm   145 NEVISNRAIEILGGELGSKKPVHPNDHVNMSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTAL 209

  Fly   204 RAKSEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAVGTGL 268
            ..|:||||||||||||||.||||||||||||.|..||..:..|:::.|||:|:||.|||||||||
Worm   210 HNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQLAAGGTAVGTGL 274

  Fly   269 NTRKGFAEKCAAKIAELTSLPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSG 333
            |||||||||.||.::|||.|||||||||||||||.||:|||||.|||:|||.|||.|||||||||
Worm   275 NTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSG 339

  Fly   334 PRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIV 398
            ||||||||||||||||||||||||||||||::||::||||||||||::|||||||||||||||||
Worm   340 PRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIV 404

  Fly   399 SNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAKIAKTAHKN 463
            .|||:|.|||:|.:.:||.:||:||.||::||||||.||||||||||||||||.|||||||||||
Worm   405 RNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKN 469

  Fly   464 GTTLKEEAINLGYLTEQQFNDWVRPEQMLGPK 495
            ||||.:||:.||.|||:||..||:||.|||||
Worm   470 GTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum1	NP_572339.1	fumC	31..495	CDD:234779	356/463 (77%)
fum-1	NP_498642.1	fumC	38..501	CDD:234779	358/473 (76%)
fum-1	NP_498642.1	Fumarase_classII	42..497	CDD:176465	353/455 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167431
Domainoid	1	1.000	522	1.000	Domainoid score	I148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115
Inparanoid	1	1.050	722	1.000	Inparanoid score	I327
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm14286
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	LDO	PTHR11444
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R461
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890