DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum1 and Fh1

DIOPT Version :9

Sequence 1:	NP_572339.1	Gene:	Fum1 / 31605	FlyBaseID:	FBgn0286222	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_034339.2	Gene:	Fh1 / 14194	MGIID:	95530	Length:	507	Species:	Mus musculus

Alignment Length:	479	Identity:	366/479 - (76%)
Similarity:	413/479 - (86%)	Gaps:	2/479 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TKPWAAIGSLRLASQ-EFRVESDTFGELKVPADKYYGAQTMRSQINFPIGGATERMPKPVVQAMG 81
            |.|..|....|:||| .||||.|||||||||.||||||||:||.:||.|||||||||.||:||.|
Mouse    30 TLPRCAPNVARMASQNSFRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFG 94

  Fly    82 ILKKAAAEVNKEFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGSGTQSNMNVNEVISNRA 146
            |||:||||||:|:|||.|::.||.||||:|..||| :||||||:||||||||:||||||||||||
Mouse    95 ILKRAAAEVNQEYGLDPKIASAIMKAADEVAEGKL-NDHFPLVVWQTGSGTQTNMNVNEVISNRA 158

  Fly   147 IELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPAIKTLHDALRAKSEEFK 211
            ||:|||:||||.|||||||||||||||||||||:||:.|:|::..|.|.::.|||||.|||:||.
Mouse   159 IEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFA 223

  Fly   212 DIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAVGTGLNTRKGFAE 276
            .:||||||||.||||||||||||||.||:.||..||.|.:||:||||.||||||||||||.||||
Mouse   224 QVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAE 288

  Fly   277 KCAAKIAELTSLPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGEL 341
            |.|||:|.||.|||||||||||||||.||:||:.|.:||.|.|||||||||||||||||.|||||
Mouse   289 KVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGEL 353

  Fly   342 SLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIVSNVLRSIR 406
            .|||||||||||||||||||||::||::||||||.||||:||||||||||||||:::.|||.|.|
Mouse   354 ILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSAR 418

  Fly   407 LLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAKIAKTAHKNGTTLKEEA 471
            ||.|.|.:||.|||.|||||.|.|.|:|||||||||||||||||||||||||||||||:||||.|
Mouse   419 LLGDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETA 483

  Fly   472 INLGYLTEQQFNDWVRPEQMLGPK 495
            |.|||||.:||::||:|:.|||||
Mouse   484 IELGYLTAEQFDEWVKPKDMLGPK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum1	NP_572339.1	fumC	31..495	CDD:234779	359/464 (77%)
Fh1	NP_034339.2	fumC	46..507	CDD:234779	357/461 (77%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	142..144		1/1 (100%)
		Substrate binding (B site). /evidence=ECO:0000250\|UniProtKB:P05042	173..176		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	183..185		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P9WN93	368..370		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850284
Domainoid	1	1.000	522	1.000	Domainoid score	I300
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115
Inparanoid	1	1.050	730	1.000	Inparanoid score	I613
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	1	1.010	-	-		QHG61095
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm42598
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	LDO	PTHR11444
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R461
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740