DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and MCM3

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_010882.1	Gene:	MCM3 / 856680	SGDID:	S000000758	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	798	Identity:	236/798 - (29%)
Similarity:	350/798 - (43%)	Gaps:	218/798 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GIRAQKLFQDFLEEF-----------------------------------KEDG-EIKYTRPAAS 46
            |.|.:: ||:||:.|                                   .:|| :::..:.|||
Yeast    22 GDRVRR-FQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAAS 85

  Fly    47 LES----PDRCTLEVSFEDVEKYDQNLATAI-IEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYV 106
            ..|    |.|  :.:|.:|:.::|::..:.| :|..|.|.|              ..|...|...
Yeast    86 STSLNILPHR--IIISLDDLREFDRSFWSGILVEPAYFIPP--------------AEKALTDLAD 134

  Fly   107 AFTEVP--------TRH---------------KVRDLTTSKIGTLIRISGQVVRTHPVHPELVSG 148
            :..:||        :||               ..|.||...:..|:.:.|.|.:|..|.|:|:..
Yeast   135 SMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRS 199

  Fly   149 VFMC-----------LDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRI 202
            |...           .|..|.:..     :...|.|.........| ...:...|.|:|.|:|.:
Yeast   200 VHYAAKTGRFHYRDYTDATTTLTT-----RIPTPAIYPTEDTEGNK-LTTEYGYSTFIDHQRITV 258

  Fly   203 QETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPG 267
            ||.....|.|.:||::::||..:||:..:.|||.:..|         |...:|....|.|
Yeast   259 QEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVG---------VFKSLGAGGMNQS----- 309

  Fly   268 EGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEM 332
             ..:.:.|.|.|          .|..:|....||..|       |.|..|   :||.:...|.::
Yeast   310 -NSNTLIGFKTL----------ILGNTVYPLHARSTG-------VAARQM---LTDFDIRNINKL 353

  Fly   333 SKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQF 397
            ||.::::..|..||.|||||:|.:|:.|||...|||.|.....:.||||||:.:||||||||||.
Yeast   354 SKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQL 418

  Fly   398 LKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQ 462
            |:.|.:.:..||.|:|:.||..||||||..|.|:.:..:||||::|||.|:.||||||||...|:
Yeast   419 LRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDR 483

  Fly   463 VAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFI 527
            |||||.|||||::||:||:..|||||.|::|||||:.|:||.::...|||.|...::|||||.|:
Yeast   484 VAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFV 548

  Fly   528 LVDECNEVVDYAIARKIV----------------------------------DLHSNIEESVERA 558
            :.|:.||:.|.:|:..::                                  :.|||....||..
Yeast   549 VTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENE 613

  Fly   559 ----------------------------YTREEVLRYVT--FARQFK--------PVISQEAGHM 585
                                        |...|:.:.||  |.|::.        |.::|||.::
Yeast   614 GEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINV 678

  Fly   586 LVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIR 650
            :|:||..||..|.....    .||.|.||::|||:.|.||:..|..|.:...|.|..||..::
Yeast   679 IVKNYTDLRNDDNTKKS----PITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFAL-- 737

  Fly   651 VEQPDIHLDDDEGLDMDD 668
                   |.:|.|.|:|:
Yeast   738 -------LGEDIGNDIDE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	23/124 (19%)
		MCM	113..649	CDD:214631	204/633 (32%)
		MCM6_C	702..816	CDD:375690
MCM3	NP_010882.1	MCM_N	25..>137	CDD:405270	23/128 (18%)
MCM3	NP_010882.1	MCM	166..738	CDD:214631	202/625 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810