DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and MCM4

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_015344.1	Gene:	MCM4 / 856130	SGDID:	S000006223	Length:	933	Species:	Saccharomyces cerevisiae

Alignment Length:	824	Identity:	265/824 - (32%)
Similarity:	402/824 - (48%)	Gaps:	164/824 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FQDFLEEFK-----------------EDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATA 72
            |::||..||                 .|.|:.|.:....:.......|.:...::..|.|.
Yeast   194 FRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQT---- 254

  Fly    73 IIEEYYHIYPFLCQSVSNYVKDRIGL--KTQKDCYVA----------FTEVPTR-HKV------- 117
              |:.||       .:.||.::.|.:  :|.|||.|:          ..|:.|: :||
Yeast   255 --EDLYH-------QLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGS 310

  Fly   118 ----RDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQ----TEI-RNVEQQFKFTNPTI 173
                |:|..:.|..||.:.|.|:|:.||.|::....|.|..|.    .|| |.|.|:     |..
Yeast   311 CKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQE-----PAR 370

  Fly   174 CRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDF 238
            |....|:......|...:..|.|.|.|::|||...:|.|..|.::.:.:..|||::.:||||.:.
Yeast   371 CERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEV 435

  Fly   239 TGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFG 303
            |||...:|         .||.:..|           .||:|      |:.......|:..:.:
Yeast   436 TGTFRSIP---------IRANSRQR-----------VLKSL------YKTYVDVVHVKKVSDK-- 472

  Fly   304 GTDLPMSEVTAEDMK-----------KQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVK 357
            ..|:..|.:..|.|:           :|:||.:..||.|::...:||..|..|:.||||..::||
Yeast   473 RLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVK 537

  Fly   358 RGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLT 422
            :|||||.|||..||.|:....|||||:.:.|||||:|||.|:.|...:||.:|||||.|||.|||
Yeast   538 KGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLT 602

  Fly   423 AAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNA 487
            |.:.||.::...|:|:|||:|:|.|:|||||||||....:..:||.|||||||||:||:..||||
Yeast   603 AYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNA 667

  Fly   488 RTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIE 552
            |:||||:||||..||:.:..:.:||.|..|::|||||.::::|:.:|..|..:|:.:.:|:  :|
Yeast   668 RSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLY--LE 730

  Fly   553 ESVERAYTREEVL------RYVTFARQ-FKPVISQEAGHMLVENY-GHLRQRDTGTSGRSTWRIT 609
            :..|. .::::||      .|:::|:: ..|:|::.|...||..| |..:..|...|.......|
Yeast   731 DKPEH-ISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITAT 794

  Fly   610 VRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDI 674
            .|||||||||:||.||::..|.|....|:||.||:..:|           .|...|...|   .|
Yeast   795 TRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAI-----------KDYATDPKTG---KI 845

  Fly   675 DMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIK 739
            ||            |.:.|..|...:|.:..||.|         ::::..::|...:..|:. ||
Yeast   846 DM------------NLVQTGKSVIQRKLQEDLSRE---------IMNVLKDQASDSMSFNEL-IK 888

  Fly   740 RSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVII 783
            :.|      |...|::||.|        |::.:.||...|:||:
Yeast   889 QIN------EHSQDRVESSD--------IQEALSRLQQEDKVIV 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	22/112 (20%)
		MCM	113..649	CDD:214631	212/571 (37%)
		MCM6_C	702..816	CDD:375690	19/82 (23%)
MCM4	NP_015344.1	MCM_N	194..306	CDD:405270	26/124 (21%)
MCM4	NP_015344.1	MCM	310..834	CDD:214631	210/570 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810