Protein Alignment Mcm6 and MCM4

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_015344.1
• Gene: MCM4 / 856130
• SGDID: S000006223
• Length: 933
• Species: Saccharomyces cerevisiae
• Alignment Length: 824
• Identity: 265/824 - (32%)
• Similarity: 402/824 - (48%)
• Gaps: 164/824 - (19%)

  Fly    25 FQDFLEEFK-----------------EDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATA 72
            |::||..||                 .|.|:.|.:....:.......|.:...::..|.|.
Yeast   194 FRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQT---- 254

  Fly    73 IIEEYYHIYPFLCQSVSNYVKDRIGL--KTQKDCYVA----------FTEVPTR-HKV------- 117
              |:.||       .:.||.::.|.:  :|.|||.|:          ..|:.|: :||
Yeast   255 --EDLYH-------QLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGS 310

  Fly   118 ----RDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQ----TEI-RNVEQQFKFTNPTI 173
                |:|..:.|..||.:.|.|:|:.||.|::....|.|..|.    .|| |.|.|:     |..
Yeast   311 CKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQE-----PAR 370

  Fly   174 CRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDF 238
            |....|:......|...:..|.|.|.|::|||...:|.|..|.::.:.:..|||::.:||||.:.
Yeast   371 CERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEV 435

  Fly   239 TGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFG 303
            |||...:|         .||.:..|           .||:|      |:.......|:..:.:
Yeast   436 TGTFRSIP---------IRANSRQR-----------VLKSL------YKTYVDVVHVKKVSDK-- 472

  Fly   304 GTDLPMSEVTAEDMK-----------KQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVK 357
            ..|:..|.:..|.|:           :|:||.:..||.|::...:||..|..|:.||||..::||
Yeast   473 RLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVK 537

  Fly   358 RGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLT 422
            :|||||.|||..||.|:....|||||:.:.|||||:|||.|:.|...:||.:|||||.|||.|||
Yeast   538 KGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLT 602

  Fly   423 AAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNA 487
            |.:.||.::...|:|:|||:|:|.|:|||||||||....:..:||.|||||||||:||:..||||
Yeast   603 AYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNA 667

  Fly   488 RTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIE 552
            |:||||:||||..||:.:..:.:||.|..|::|||||.::::|:.:|..|..:|:.:.:|:  :|
Yeast   668 RSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLY--LE 730

  Fly   553 ESVERAYTREEVL------RYVTFARQ-FKPVISQEAGHMLVENY-GHLRQRDTGTSGRSTWRIT 609
            :..|. .::::||      .|:::|:: ..|:|::.|...||..| |..:..|...|.......|
Yeast   731 DKPEH-ISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITAT 794

  Fly   610 VRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDI 674
            .|||||||||:||.||::..|.|....|:||.||:..:|           .|...|...|   .|
Yeast   795 TRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAI-----------KDYATDPKTG---KI 845

  Fly   675 DMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIK 739
            ||            |.:.|..|...:|.:..||.|         ::::..::|...:..|:. ||
Yeast   846 DM------------NLVQTGKSVIQRKLQEDLSRE---------IMNVLKDQASDSMSFNEL-IK 888

  Fly   740 RSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVII 783
            :.|      |...|::||.|        |::.:.||...|:||:
Yeast   889 QIN------EHSQDRVESSD--------IQEALSRLQQEDKVIV 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	22/112 (20%)
		MCM	113..649	CDD:475121	212/571 (37%)
		MCM6_C	702..816	CDD:465688	19/82 (23%)
MCM4	NP_015344.1	MCM_N	194..307	CDD:464206	26/125 (21%)
		MCM	310..834	CDD:214631	210/570 (37%)