Protein Alignment Mcm6 and MCM6

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_011314.2
• Gene: MCM6 / 852673
• SGDID: S000003169
• Length: 1017
• Species: Saccharomyces cerevisiae
• Alignment Length: 912
• Identity: 366/912 - (40%)
• Similarity: 533/912 - (58%)
• Gaps: 119/912 - (13%)

  Fly    12 RVKDEVGIRAQKLFQDFLEEFK----EDGEIK--YTRPAASLESPDRCTLEVSFEDVEKYDQN-L 69
            :|.|..|.:.::.|:.|||:|.    :.||::  |......::..|..|:.:.::.:...:.. |
Yeast   102 KVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGAL 166

  Fly    70 ATAIIEEYYHIYPFLCQSVSNYVK-------------------------------DRIGL----- 98
            |.||.|:||...|||.:.:...|:                               |..|.
Yeast   167 AMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRD 231

  Fly    99 --------------------------KTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVR 137
                                      :|::...::|..:||.|::||:.:.|||:|:.|||.|.|
Yeast   232 SGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTR 296

  Fly   138 THPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRI 202
            |..|.|||....|.|..|:..:.||||.||:|.||.|.||.|.||..:.|:|.:|.|||:||:||
Yeast   297 TSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRI 361

  Fly   203 QETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENS----SR 263
            ||...|:|.|.:||.:::|||.:.||..:.|||..|||..||||||:.|...|.:..::    ..
Yeast   362 QENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGI 426

  Fly   264 HKPGEGMD-GVTGLKALGMRELNYRMAFLACSVQATTARFGG-----------TDLPM------- 309
            .|..||:: |||||::||:|:|.|:::||||.|.:..:..|.           |:|.|
Yeast   427 SKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQAN 491

  Fly   310 -----SEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVA 369
                 :|...|.....::..|.:::.||.||.::|..|:.|:.|:::|::.||:|||||..|||.
Yeast   492 NVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVH 556

  Fly   370 KTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDF 434
            |:|.|...||||||:|:||||||:||||||.|..|:||::|||||||||||||||||||||..|:
Yeast   557 KSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDY 621

  Fly   435 VIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPIN 499
            .|||||||||||||||||||||||..|||||||||||||||||:||:.|||||||||||||||:.
Yeast   622 TIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVG 686

  Fly   500 GRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEV 564
            |||:|..||:.|:.::|||||||||||:::|:|||.:|..:|..|||||...:|::|..::.|::
Yeast   687 GRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQL 751

  Fly   565 LRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECS 629
            .||:.:||.|||::::||...|||.|..||:.|.....||::||||||||||||||||:|:..|.
Yeast   752 RRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCV 816

  Fly   630 NRVLERHVKEAFRLLNKSIIRVEQPDIHLDDD-------------EGLDMDDGIQHDIDMENNGA 681
            :.:....:.||:.||.:|||||:..|:.:|::             ...|.|||....:  ..:..
Yeast   817 DEITPSFIAEAYDLLRQSIIRVDVDDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGV--ITSEP 879

  Fly   682 AANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTW 746
            .|:::|.....|:..|..:|||.|::::.|.::..|:|..:    |..:.||.:. :...::|.|
Yeast   880 PADIEEGQSEATARPGTSEKKKTTVTYDKYVSMMNMIVRKI----AEVDREGAEE-LTAVDIVDW 939

  Fly   747 YLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVH 811
            ||.|..:.:.|..|....:.|..|:|.||: .|::::.:..:....| .::.:..|.:..:.|:|
Yeast   940 YLLQKENDLGSLAEYWEERRLAFKVIKRLV-KDRILMEIHGTRHNLR-DLENEENENNKTVYVIH 1002

  Fly   812 PN 813
            ||
Yeast  1003 PN 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	24/155 (15%)
		MCM	113..649	CDD:475121	294/563 (52%)
		MCM6_C	702..816	CDD:465688	28/112 (25%)
MCM6	NP_011314.2	MCM_N	112..195	CDD:464206	21/82 (26%)
		MCM	272..836	CDD:214631	294/563 (52%)
		MCM6_C	900..1007	CDD:465688	28/112 (25%)