Protein Alignment Mcm6 and MCM7

DIOPT Version :9

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_009761.4
• Gene: MCM7 / 852501
• SGDID: S000000406
• Length: 845
• Species: Saccharomyces cerevisiae
• Alignment Length: 802
• Identity: 250/802 - (31%)
• Similarity: 374/802 - (46%)
• Gaps: 151/802 - (18%)

  Fly     2 DVADAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEIKYTR-PAASLESPDRCTLEVSFEDVEKY 65
            ||.|..:.|.|:::|      ::..|...|.:.:..:..|. |.:|:....|   ||..::.|.:
Yeast   137 DVLDVILNQRRLRNE------RMLSDRTNEIRSENLMDTTMDPPSSMNDALR---EVVEDETELF 192

  Fly    66 DQNLATAIIEEYYHIYPFLCQSVS-NYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLI 129
            ..||.    ..|:..:..|.|:.: .|.|..|..|..              .||.:....:|.||
Yeast   193 PPNLT----RRYFLYFKPLSQNCARRYRKKAISSKPL--------------SVRQIKGDFLGQLI 239

  Fly   130 RISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRK---RFMLDVEK 191
            .:.|.:.|...|.|.:....:.|..|..|:........||..:.|.:..||..:   :..:....
Yeast   240 TVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRA 304

  Fly   192 SLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGT 256
            |.|..||:.:|||...::|.|.|||::.|.:...||.::..||..|.||..:..|
Yeast   305 SKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAP---------- 359

  Fly   257 RAENSSRHKPGEGMDGVTGLKAL--GMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKK 319
                            .||.|||  |:....|..|......:...|.|..|
Yeast   360 ----------------YTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLT-------------- 394

  Fly   320 QMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINV 384
              :|.| .::.|:....::|..|..|:.|.||||.:||:.:||...|||.|...:...:||||||
Yeast   395 --SDVE-ERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINV 456

  Fly   385 CIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGIC 449
            |::|||..||||.||.:...|||.:||:||.||..||||||::|..:.:.::|.|||:|||||||
Yeast   457 CLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGIC 521

  Fly   450 CIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQL 514
            |||||||||:.|:.||||.||||||||::||:..||||||||||||||:.|||:...|...||.|
Yeast   522 CIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINL 586

  Fly   515 SAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEE------SVERAYTREEVLRYVTFARQ 573
            .|.::||||:.|:::|..:...|..:|..:..:|.:.::      .||.:..||    |:.:|:.
Yeast   587 PAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMRE----YIAYAKT 647

  Fly   574 FKPVISQEAGHMLVENYGHLRQ--RDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERH 636
            .:||:|:.....:|:.|..|||  :....|..|..:.|.|.|..:||||:|:|||..::.|....
Yeast   648 KRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDD 712

  Fly   637 VKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQK 701
            |:||.||     :||.:..::.:.::..:                    ||:   .|:....:.|
Yeast   713 VEEALRL-----VRVSKESLYQETNKSKE--------------------DES---PTTKIFTIIK 749

  Fly   702 K------KFTLSFED-YKNLS----TMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQI 755
            |      |.|||:|: .|.:.    |||.|      :.|..|       .|.:..|:|....:.:
Yeast   750 KMLQETGKNTLSYENIVKTVRLRGFTMLQL------SNCIQE-------YSYLNVWHLINEGNTL 801

  Fly   756 ----------ESEDELISRKNL 767
                      :.||.|:|...|
Yeast   802 KFVDDGTMDTDQEDSLVSTPKL 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	18/85 (21%)
		MCM	113..649	CDD:214631	199/548 (36%)
		MCM6_C	702..816	CDD:375690	21/87 (24%)
MCM7	NP_009761.4	MCM_N	52..>123	CDD:405270
		MCM	223..724	CDD:214631	202/566 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810