Protein Alignment Mcm6 and MCM2

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_009530.1
• Gene: MCM2 / 852258
• SGDID: S000000119
• Length: 868
• Species: Saccharomyces cerevisiae
• Alignment Length: 706
• Identity: 219/706 - (31%)
• Similarity: 351/706 - (49%)
• Gaps: 130/706 - (18%)

  Fly    21 AQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAII---EEYYHIYP 82
            |::|....||...|.|...|.....:|...:..:|||::..:.:....||..:.   ||...|:.
Yeast   208 ARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFD 272

  Fly    83 FLCQSVS-----NYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVH 142
            .:....:     :|.      :...:.:|..::.||.:.:|:|..|.:.:|:|::|.|.|...|.
Yeast   273 LVAMEATELHYPDYA------RIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVF 331

  Fly   143 PELVSGVFMCLDCQT------EIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIR 201
            |:|....|.||.|.:      :..|.|.:..|     |.|  |.::..|.::.||:::.::|::.
Yeast   332 PQLKYVKFNCLKCGSILGPFFQDSNEEIRISF-----CTN--CKSKGPFRVNGEKTVYRNYQRVT 389

  Fly   202 IQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKP 266
            :||....:|.|.:||..|:||.::||                   |||               ||
Yeast   390 LQEAPGTVPPGRLPRHREVILLADLV-------------------DVS---------------KP 420

  Fly   267 GEGMDGVTGL-KALGMRELNYRMAF--LACSVQA--------TTARFGGTDLPMSEVTAEDMKKQ 320
            ||.:: |||: |......||.:..|  .|..::|        .||..|...|.:...|.|:
Yeast   421 GEEVE-VTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE---- 480

  Fly   321 MTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVC 385
              :.|:.||   |:||.:...:|||:.|||||:.::|..:....||||.|....|.|:||||||.
Yeast   481 --EREFRKI---SRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL 540

  Fly   386 IVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICC 450
            ::|||.|||||.||.|...:.||::.:|:.:||.||||:|.:|..:.::.:|.|||:|||.|:|.
Yeast   541 LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCL 605

  Fly   451 IDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLS 515
            |||||||:.:|:.:||||||||:|||::||:..||.||.||:|||||..|||:.:..|.||:.|:
Yeast   606 IDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLT 670

  Fly   516 APIMSRFDLFFILVDECNEVVDYAIARKIVDLH-----------------SNIEESVE------- 556
            .||:||||:..::.|..:|..|..:|..:||.|                 :|.|.::|
Yeast   671 EPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEIN 735

  Fly   557 -----------RAYTREE---------VLRYVTFAR-QFKPVISQEAGHMLVENYGHLRQRDTGT 600
                       |...:||         :::|:.:|| :..|.:.|.....:...|..||:....|
Yeast   736 EQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESIST 800

  Fly   601 SGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDI 656
               .::.||||.|||::|::|:.||:..|..|....:..|.:::..|.:..::..:
Yeast   801 ---GSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSV 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	17/94 (18%)
		MCM	113..649	CDD:475121	200/597 (34%)
		MCM6_C	702..816	CDD:465688
MCM2	NP_009530.1	MCM2_N	49..193	CDD:403724
		MCM_N	209..299	CDD:464206	17/95 (18%)
		MCM	302..846	CDD:214631	200/597 (34%)