DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and MCM8

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001268450.1	Gene:	MCM8 / 84515	HGNCID:	16147	Length:	880	Species:	Homo sapiens

Alignment Length:	819	Identity:	221/819 - (26%)
Similarity:	357/819 - (43%)	Gaps:	193/819 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLE---SPDRCTL--------EVSFEDVEKYDQ 67
            |||:. |...:..|| :|..|.||:....|..:.|   :|:: ||        :|..:|:|::..
Human   112 KDEIE-RKGSILVDF-KELTEGGEVTNLIPDIATELRDAPEK-TLACMGLAIHQVLTKDLERHAA 173

  Fly    68 NLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRH----------KVRDLTT 122
            .|                       :.:.||....:..|   .||..|          :::::..
Human   174 EL-----------------------QAQEGLSNDGETMV---NVPHIHARVYNYEPLTQLKNVRA 212

  Fly   123 SKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQF-----KFTNPTICRNPVCSNR 182
            :..|..|.:.|.|||...:.|......|:|..| .||    |.|     |::.||.|..|||..|
Human   213 NYYGKYIALRGTVVRVSNIKPLCTKMAFLCAAC-GEI----QSFPLPDGKYSLPTKCPVPVCRGR 272

  Fly   183 KRFML-DVEKSLFLDFQKIRIQETQAELPR--GCIPRAVEIILRSELVETVQAGDRYDFTGTLIV 244
            ....| ....::.:|:|.|:|||..::..|  |.|||.:|..|..:||::...||....||.:.|
Human   273 SFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKV 337

  Fly   245 VPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPM 309
                       :.||..||:|                   |.:..||......:.:...|.....
Human   338 -----------SNAEEGSRNK-------------------NDKCMFLLYIEANSISNSKGQKTKS 372

  Fly   310 SEVTAE-DMKKQMTDAEWHKIYEMSKDRNLYQNLIS---SLFPSI---------------YGNDE 355
            ||...: .|..:.:..:.:.|.|:..:.||::.::.   :|.|.:               ..|..
Human   373 SEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSS 437

  Fly   356 ----------------------VKRGILLQQFGGVAKTTTEKT--SLRGDINVCIVGDPSTAKSQ 396
                                  ||.|:.|..|||..|...:|.  .:|||.::.:||||...|||
Human   438 PTSACRVAGTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQ 502

  Fly   397 FLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRD 461
            .|:...:.:||.:|..|..::.:|||..:.:|..|.||.:|||||:|.|.|||.|||||||..:.
Human   503 MLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQH 567

  Fly   462 QVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFF 526
            | |:.||||||:||:|:|||..:|.|||||:|||||:.|.|:::|::.:|:::.:.::|||||.|
Human   568 Q-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVF 631

  Fly   527 ILVDECNEVVDYAIARKIVDLHSNIEESVERAYTRE-----------EVL--------------- 565
            ||:|..||..|:.::..::.:.:..:.::..|....           ||:
Human   632 ILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGE 696

  Fly   566 -----------RYVTFARQF-KPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIR 618
                       :|:.:|||: .|.:|.||..:|.:.|..||::....:...   ||.|||||:||
Human   697 TIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP---ITTRQLESLIR 758

  Fly   619 LSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAA 683
            |:||.|:||......:...::...::..|::     ..:.|:...||.:.. ||...|.|...|.
Human   759 LTEARARLELREEATKEDAEDIVEIMKYSML-----GTYSDEFGNLDFERS-QHGSGMSNRSTAK 817

  Fly   684 NVDE--NNGMDTSASGAVQ-------KKKFTLSFEDYKN 713
            ....  ||..:.:.:...|       .|:..:...|::|
Human   818 RFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFEN 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	18/94 (19%)
		MCM	113..649	CDD:214631	183/634 (29%)
		MCM6_C	702..816	CDD:375690	3/12 (25%)
MCM8	NP_001268450.1	MCM_N	98..223	CDD:291233	27/139 (19%)
		Mcm2	139..877	CDD:224162	211/790 (27%)
		AAA	475..633	CDD:99707	75/158 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820