DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and MCM2

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_175112.2	Gene:	MCM2 / 841056	AraportID:	AT1G44900	Length:	936	Species:	Arabidopsis thaliana

Alignment Length:	811	Identity:	246/811 - (30%)
Similarity:	394/811 - (48%)	Gaps:	170/811 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GQLR---VKDEVGIRAQKLFQDFLEEF----KEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYD 66
            |.||   ::|||.....|.|:|||..:    .|:|:|:|.|....:.|.::|:||:.:::.....
plant   203 GTLREWVMRDEVRRFIAKKFKDFLLTYVKPKNENGDIEYVRLINEMVSANKCSLEIDYKEFIHVH 267

  Fly    67 QNLA----------TAIIEE-----YYHIYPFLCQSVSNY--VKDRIGLKTQKDCYVAFTEVPTR 114
            .|:|          ..::||     .:.::|       ||  :..:|        ||..|.:|..
plant   268 PNIAIWLADAPQPVLEVMEEVSEKVIFDLHP-------NYKNIHTKI--------YVRVTNLPVN 317

  Fly   115 HKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEI----RNVEQQFKFTNPTICR 175
            .::|::....:.|:|||.|.|.|...|.|:|....:.|..|...:    :|...:.|..:   |.
plant   318 DQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCNKCGAVLGPFFQNSYSEVKVGS---CS 379

  Fly   176 NPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTG 240
            .  |.::..|.::||::::.::||:.|||:...:|.|.:||..|:||.::|::..:.|:..:.||
plant   380 E--CQSKGPFTVNVEQTIYRNYQKLTIQESPGTVPAGRLPRHKEVILLNDLIDCARPGEEIEVTG 442

  Fly   241 TLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAF--LACSVQATTARFG 303
            ......|:|                                  ||.:..|  .|..|:|
plant   443 IYTNNFDLS----------------------------------LNTKNGFPVFATVVEA------ 467

  Fly   304 GTDLPMSEVTAEDMKKQ-------MTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGIL 361
                  :.||    |||       :|..:..:|.|:|||..:.:.:|.|:.|||||::::|..:.
plant   468 ------NYVT----KKQDLFSAYKLTQEDKTQIEELSKDPRIVERIIKSIAPSIYGHEDIKTALA 522

  Fly   362 LQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVV 426
            |..|||..|....|..|||||||.::|||.||||||||.|.....||:||:||.:||.||||||.
plant   523 LAMFGGQEKNIKGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGQRAVYTTGKGASAVGLTAAVH 587

  Fly   427 RDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSI 491
            :|..:.::.:|.|||:|||.|||.|||||||:.:|:|:||||||||:|||::||:..:|.||.|:
plant   588 KDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSV 652

  Fly   492 LAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLH-------- 548
            :|||||:.||||.|||..||::|:.||:||||:..::.|..:.|.|..:|..:|:.|
plant   653 IAAANPVGGRYDSSKSFAQNVELTDPILSRFDILCVVKDVVDPVTDEMLAEFVVNSHFKSQPKGG 717

  Fly   549 ----SNIEESVE--RAYTREEVL------RYVTFARQFK-PVISQEAGHMLVENYGHLRQRDTGT 600
                |:.|:.::  ...|..|||      :|:|:::.:. |.:.:.....|...|.:||:.....
plant   718 KMEDSDPEDGIQGSSGSTDPEVLPQNLLKKYLTYSKLYVFPKLGELDAKKLETVYANLRRESMNG 782

  Fly   601 SGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLD 665
            .|.|   |..|.||||||:|||.|::.....|.|..|..|.|:|..|.|..::
plant   783 QGVS---IATRHLESMIRMSEAHARMHLRQYVTEEDVNMAIRVLLDSFISTQK------------ 832

  Fly   666 MDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCE 730
              .|:|..:                       ....|::....:|:.:|..:|:..:.....:.|
plant   833 --FGVQRTL-----------------------RESFKRYITYKKDFNSLLLVLLKELVKNALKFE 872

  Fly   731 --VEGNDTGIKRSNVVTWYLEQVADQIESED 759
              :.|:::|:....|....|:..|.:.:..|
plant   873 EIISGSNSGLPTIEVKIEELQTKAKEYDIAD 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	23/104 (22%)
		MCM	113..649	CDD:214631	200/569 (35%)
		MCM6_C	702..816	CDD:375690	11/60 (18%)
MCM2	NP_175112.2	MCM2_N	67..>138	CDD:372227
		MCM_N	222..313	CDD:379644	23/105 (22%)
		MCM	320..828	CDD:214631	200/565 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820