DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and PRL

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001190655.1	Gene:	PRL / 828153	AraportID:	AT4G02060	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	710	Identity:	228/710 - (32%)
Similarity:	348/710 - (49%)	Gaps:	138/710 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LFQDFLEEFKE-DGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQS 87
            |.:.|||.|.: :|..||......:.:.....::|..:|:..|.        :|.......|.::
plant    12 LAKGFLENFADANGRSKYMEILQEVSNRKIRAIQVDLDDLFNYK--------DESEEFLGRLTEN 68

  Fly    88 VSNYVK--------------------DRIGLKTQ----------------------KDCYVAFTE 110
            ...||.                    |...|.||                      |..|..:.:
plant    69 TRRYVSIFSAAVDELLPEPTEAFPDDDHDILMTQRADDGTDNPDVSDPHQQIPSEIKRYYEVYFK 133

  Fly   111 VPTRHK---VRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEI------RNVEQQF 166
            .|::.:   :|::..|.||.|:||||.|.|...|.|.:...|:.|.||..||      |.....|
plant   134 APSKGRPSTIREVKASHIGQLVRISGIVTRCSDVKPLMAVAVYTCEDCGHEIYQEVTSRVFMPLF 198

  Fly   167 KFTNPTICR------NPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSE 225
            |..: :.||      ||:        |.:..|.||.||:.::||....:|:|.|||::.:.||.|
plant   199 KCPS-SRCRLNSKAGNPI--------LQLRASKFLKFQEAKMQELAEHVPKGHIPRSMTVHLRGE 254

  Fly   226 LVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAF 290
            |...|..||..:|:|..:.:|                          .||.|||       |...
plant   255 LTRKVSPGDVVEFSGIFLPIP--------------------------YTGFKAL-------RAGL 286

  Fly   291 LACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHK-----IYEMSKDRNLYQNLISSLFPSI 350
            :|           .|.|..:.||  ..||:..:.|:.|     |..:::|.::|..|..||.|.|
plant   287 VA-----------DTYLEATSVT--HFKKKYEEYEFQKDEEEQIARLAEDGDIYNKLSRSLAPEI 338

  Fly   351 YGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKA 415
            ||::::|:.:||...|...:...:...:|||:::|::|||..||||.||.:.:.:||.:||:||.
plant   339 YGHEDIKKALLLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLKHIINVAPRGVYTTGKG 403

  Fly   416 SSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAG 480
            ||..||||||:||:.:.:.|:|.|||:|||.|||.||||||||:.|:.||||.|||||:|||:||
plant   404 SSGVGLTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHEVMEQQTVSIAKAG 468

  Fly   481 VRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIV 545
            :..:|||||::||||||..||||..::..:||.|...::|||||.::::|..:...|..:|:.::
plant   469 ITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLILDRADMDSDLELAKHVL 533

  Fly   546 DLHSNIEESVERAYTREE--VLR-YVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWR 607
            .:|.. |||....:...|  :|| |::.||:..|.:..|....:...|..:||.:..::...::
plant   534 HVHQT-EESPALGFEPLEPNILRAYISAARRLSPYVPAELEEYIATAYSSIRQEEAKSNTPHSY- 596

  Fly   608 ITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDE--GLD 665
            .|||.|.|::|:|.|:|:|..|..|.:..|.||.||:..|.|     .::.||.:  |||
plant   597 TTVRTLLSILRISAALARLRFSESVAQSDVDEALRLMQMSKI-----SLYADDRQKAGLD 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	20/126 (16%)
		MCM	113..649	CDD:214631	200/558 (36%)
		MCM6_C	702..816	CDD:375690
PRL	NP_001190655.1	MCM_N	16..98	CDD:405270	15/89 (17%)
PRL	NP_001190655.1	MCM	139..638	CDD:214631	200/555 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820