DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and MCM9

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001318221.1	Gene:	MCM9 / 815890	AraportID:	AT2G14050	Length:	651	Species:	Arabidopsis thaliana

Alignment Length:	646	Identity:	183/646 - (28%)
Similarity:	310/646 - (47%)	Gaps:	135/646 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AQKLFQD---FLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYP 82
            |:::|.|   :|.:|.:...:.:               :::.|.::|:::.:  .|.:.:.|:
plant    56 ARQVFSDPEHYLRQFDDSAILAH---------------KIALEHMKKFEEKI--GIEKRFIHV-- 101

  Fly    83 FLCQSVSNYVKDRIG-----LKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVH 142
                        ||.     |:...:.:.:...|..:|:         |.|:.:.|.|:|:..|.
plant   102 ------------RINTSGSPLERSPETFPSIGRVRVKHR---------GILMMLKGTVIRSGAVK 145

  Fly   143 PELVSGVFMCLDCQ------TEIRNVEQQFKFTNPTIC---RNPVCSNRKRFMLD--VEKSLFLD 196
            ......::.|..|:      .|:.::....|   |..|   |:..|.......:|  |.:.   |
plant   146 MYEGEKMYRCRKCKHMFPIFPELESINSIVK---PPFCPSQRSKACEGTNFDPVDDTVTRH---D 204

  Fly   197 FQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENS 261
            :|:|:|||....|..|.|||::.::|:.:||:.|:|||            || |::|:.|
plant   205 YQEIKIQENTQVLGVGVIPRSILVVLKDDLVDNVKAGD------------DV-VVSGILT----- 251

  Fly   262 SRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQ----ATTARFGGTDLPMSEVTAEDMKKQMT 322
                                .:.::.:..:.|.::    |...|  .|:...||:...|...:..
plant   252 --------------------SKWSHDLKDVRCDLEPMLIANHVR--RTNELKSEIDISDDLIEKF 294

  Fly   323 DAEWHKIYEMS-KDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCI 386
            ...|....:.. |.||.   ::..:.|.::|...||..:.|...|||.......|.:||:.::.:
plant   295 KNFWSHFRDTPLKGRNA---ILRGICPQVFGLFTVKLAVALTLIGGVQHVDASGTKVRGESHLLL 356

  Fly   387 VGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCI 451
            :|||.|.||||||..:..|.||:.|:|..|::||||...|:|  ..::::|||||:|||.|:|||
plant   357 IGDPGTGKSQFLKFAAKLSNRAVITTGLGSTSAGLTVTAVKD--GGEWMLEAGALVLADGGLCCI 419

  Fly   452 DEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSA 516
            ||||.|.:.|:..||||||||:||:|:||:..||:.:|.:..|.|| .|:||..:||..|..||.
plant   420 DEFDSMREHDRATIHEAMEQQSISVAKAGLVTTLSTKTIVFGATNP-KGQYDPDQSLSVNTALSG 483

  Fly   517 PIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVL---------RYVTFAR 572
            |::||||:..:|:|..|...|     .:|..|...|..:|:....:::.         ||:.|.:
plant   484 PLLSRFDIVLVLLDTKNPEWD-----AVVSSHILAEVQIEQDREVDDLTTIWPLPMLQRYIQFVK 543

  Fly   573 Q-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRV 632
            : |:||:|:|| ..::.:|..|::|   :|..:..|.|||.|||:|||::|.|:|...|.|
plant   544 KNFRPVLSKEA-EEIISSYYRLQRR---SSTHNAARTTVRMLESLIRLAQAHARLMFRNEV 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	11/91 (12%)
		MCM	113..649	CDD:214631	170/546 (31%)
		MCM6_C	702..816	CDD:375690
MCM9	NP_001318221.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820