DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and MCM5

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_178812.1	Gene:	MCM5 / 815415	AraportID:	AT2G07690	Length:	727	Species:	Arabidopsis thaliana

Alignment Length:	755	Identity:	236/755 - (31%)
Similarity:	370/755 - (49%)	Gaps:	130/755 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FQDFLEEFK-EDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIE---EYYHIYPFLC 85
            |::|:..|: |.....|..  |.|::|.|  |.|..||:..:|.:|.:.|..   :|..::....
plant    35 FKEFIRNFEIEQNCFPYRE--ALLDNPKR--LVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAA 95

  Fly    86 QSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSK-------------IGTLIRISGQVVR 137
            ..|..      |||.::.......|.|....|:.|.||:             |..|::|||..:.
plant    96 GEVLT------GLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKLVKISGISIA 154

  Fly   138 THPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPV--------CSNRKR---------- 184
            ...|..:......:|.:|           |.|....||..:        |.|..:
plant   155 ASRVKAKATYVFLVCKNC-----------KKTREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDP 208

  Fly   185 FMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVS 249
            :|:..::|.::|.|.:::||...::|.|.:||.:.:.:...||:|:..|.|....|
plant   209 WMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMG--------- 264

  Fly   250 VLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATT---ARFGGTDLPMSE 311
             :..:...:.:|:.||           .|:.:|:...|:..|..:.:|::   |.|    .|..|
plant   265 -IYSIFQASSSSNSHK-----------GAVAIRQPYIRVVGLEDTNEASSRGPANF----TPDEE 313

  Fly   312 VTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKT 376
               |:.||            .:..:::|:|:.:.:.|||:|:::|||......|||..|:..:..
plant   314 ---EEFKK------------FADSQDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSLPDGV 363

  Fly   377 SLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGAL 441
            .|||||||.::||||||||||||.|...:|.|:|||||.||||||||:|:||..:.:|.:|.||:
plant   364 KLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAM 428

  Fly   442 MLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSK 506
            :|||.|:.||||||||...|:|||||||||||||||:||:...||:|||:||||||.:||||..|
plant   429 VLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLK 493

  Fly   507 SLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEE-SVERAYTREE--VLRYV 568
            :.|.||.|...|:|||||.||:.|......|..||..|:.:|::..: |.|...::|:  :.||:
plant   494 TAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASHIIRVHASANKFSDENTDSKEDNWLKRYI 558

  Fly   569 TFAR-QFKPVISQEAGHMLVENYGHLR----QRDTGTSGRSTWRITVRQLESMIRLSEAMAKLEC 628
            .:.| :..|.:|::|...|...|..:|    :|...|...:...|||||||:::||||::||:..
plant   559 QYCRARCHPRLSKDAAENLQRKYVTIRMDMKRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRL 623

  Fly   629 SNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDT 693
            |:......|.:||:|.:.|.:...:        .|::....|..::..|...|...:....|:..
plant   624 SHEATPDDVDKAFKLFDTSTMDAAR--------SGINQQINITGEMANEIKQAETQIKRRMGIGA 680

  Fly   694 SASGAVQKKKFTLSFEDYKNLS--------TMLVLHMRAE 725
            ..|    :::.   .||...:.        .:|::|.|.|
plant   681 RLS----ERRL---IEDLARMGMNDSMVRRALLIMHQRGE 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	21/87 (24%)
		MCM	113..649	CDD:214631	201/577 (35%)
		MCM6_C	702..816	CDD:375690	6/32 (19%)
MCM5	NP_178812.1	MCM_N	35..127	CDD:379644	25/101 (25%)
MCM5	NP_178812.1	MCM	131..644	CDD:214631	197/563 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820