DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and Mcm8

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001277983.1	Gene:	Mcm8 / 66634	MGIID:	1913884	Length:	833	Species:	Mus musculus

Alignment Length:	813	Identity:	243/813 - (29%)
Similarity:	371/813 - (45%)	Gaps:	188/813 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDEVGIRAQKLFQDFLEEFKEDGEIKYTRP---AASLESPDRCTL--------EVSFEDVEKYDQ 67
            |||:. |...:..||.|..|.| ||....|   .|..::|:: ||        :|..:|:|::..
Mouse   105 KDEIE-RKGSILVDFKELTKAD-EITNLIPDIENALRDAPEK-TLACMGLAIHQVLTKDLERHAA 166

  Fly    68 NLAT--------AIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSK 124
            .|..        ..:....|||    ..|.||                   .|..| ::::..:.
Mouse   167 ELQAQEGLSNGGETMVNVPHIY----ARVYNY-------------------EPLTH-LKNIRATC 207

  Fly   125 IGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQF-----KFTNPTICRNPVCSNRKR 184
            .|..|.|.|.|||...:.|...:..|.|..| .||    |.|     |:|.||.|..|.|  |.|
Mouse   208 YGKYISIRGTVVRVSNIKPLCTNMAFQCAAC-GEI----QSFPLPDGKYTLPTKCPVPAC--RGR 265

  Fly   185 FMLDVEKS---LFLDFQKIRIQETQAELPR--GCIPRAVEIILRSELVETVQAGDRYDFTGTLIV 244
            ....:..|   :.||:|.|:|||..::..|  |.|||.:|..|..:||::...||....||.:.|
Mouse   266 SFAPLRSSPLTVTLDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKV 330

  Fly   245 VPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPM 309
                       :.:|..||:|                   |.:..||......:.:...|   |.
Mouse   331 -----------SNSEEGSRNK-------------------NDKCMFLLYIEANSVSNSKG---PK 362

  Fly   310 SEVTAEDMKKQMTDAEW-----HKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVA 369
            :: ||||..|..|..|:     :.|.|:..:.||.:.:::||.|.|:|::.||.|:.|..|||..
Mouse   363 AQ-TAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQ 426

  Fly   370 KTTTEKT--SLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESF 432
            |...:|.  .:|||.:|.|||||...|||.|:...:.:||.:|..|..::::|||..:.:|..|.
Mouse   427 KYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSG 491

  Fly   433 DFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANP 497
            ||.:|||||:|.|.|||.|||||||..:.| |:.||||||:||:|:|||..:|.|||||:|||||
Mouse   492 DFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANP 555

  Fly   498 INGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERA-YTR 561
            :.|.|::::::.:|:::.:.::|||||.|||:|..||..|:.::..::.:.:..:::|..| .||
Mouse   556 VGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTR 620

  Fly   562 -----------------------------------EEVLR-YVTFARQF-KPVISQEAGHMLVEN 589
                                               .::|| |:.:|||: .|.:|.:|...|.:.
Mouse   621 VLSQDSNTSVLEVVSEKPLSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDF 685

  Fly   590 YGHLRQRD--TGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVE 652
            |..||::.  .|:|     .||.|||||:|||:||.|:||..........::...::..|::
Mouse   686 YLELRKQSQRVGSS-----PITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSML--- 742

  Fly   653 QPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKF-----TLSFEDYK 712
              ..:.|:...||.:.. ||...|.|...|                   |:|     :::...|.
Mouse   743 --GTYSDEFGNLDFERS-QHGSGMSNRSTA-------------------KRFISALNSIAERTYN 785

  Fly   713 NLSTMLVLHMRAEEARCEVEG--------NDTG 737
            |:.....|...|:|...:|..        ||.|
Mouse   786 NIFQYHQLRQIAKELNIQVADFENFIGSLNDQG 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	22/102 (22%)
		MCM	113..649	CDD:214631	197/592 (33%)
		MCM6_C	702..816	CDD:375690	11/49 (22%)
Mcm8	NP_001277983.1	MCM_N	91..216	CDD:291233	31/137 (23%)
		Mcm2	132..830	CDD:224162	232/784 (30%)
		AAA	428..586	CDD:99707	76/158 (48%)
		PEPcase	<676..>747	CDD:304407	23/80 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820