DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm6

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001076318.1	Gene:	mcm6 / 566409	ZFINID:	ZDB-GENE-030909-6	Length:	830	Species:	Danio rerio

Alignment Length:	838	Identity:	514/838 - (61%)
Similarity:	648/838 - (77%)	Gaps:	30/838 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVADAQV----GQLRVKDEVGIRAQKLFQDFLEEFK-EDGEIKYTRPAASLESPDRCTLEVSFE 60
            ||:.:..|    ||: :|||:..:.|||||.|||||: .|||:||.|.|..|..|:|.||.|||.
Zfish     1 MDLTETGVNQNAGQV-IKDELAEKCQKLFQAFLEEFQNSDGEVKYLRDAEELIRPERNTLAVSFT 64

  Fly    61 DVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKI 125
            |:|.::|.|||||.||:|.:||:||::|.|:.::...:.|.|:.||||.::|||||:|:|||.|:
Zfish    65 DLEGFNQELATAIQEEFYRLYPYLCRAVRNFAREHGEVPTSKEFYVAFQDLPTRHKIRELTTVKV 129

  Fly   126 GTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVE 190
            |:|:|||||||||||||||||||.|:|||||..|::||||||:|.|:|||||||:||:||:||..
Zfish   130 GSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSICRNPVCNNRRRFLLDTN 194

  Fly   191 KSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVG 255
            ||.|:||||:||||||||||||.|||::|:|||:|.||:.||||:.||.|:||||||:|.||..|
Zfish   195 KSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDFIGSLIVVPDISQLATPG 259

  Fly   256 TRAENSSRHKPGEGM--DGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMK 318
            .|||.|||....:|.  :|:.||||||:|||:|::|||||.|..|..||||.::...|.|||.:|
Zfish   260 VRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNPRFGGKEIRDEEQTAESIK 324

  Fly   319 KQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDIN 383
            |||:..||.|::|||:|:|||.||.:||||:|:|||||||||||..||||.|||.|.||||||||
Zfish   325 KQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDIN 389

  Fly   384 VCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGI 448
            ||:|||||||||||||.|.:|.|||:||||||||||||||||||||||.:||||||||||||||:
Zfish   390 VCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGV 454

  Fly   449 CCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQ 513
            |||||||||:.|||||||||||||||||.:|||:|||||||||||||||::|||||||||:||:.
Zfish   455 CCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVN 519

  Fly   514 LSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFKPVI 578
            |:|||||||||||||||:||||.||||||:||||||.||.||:|.|:.:|:.||:.|||||||.|
Zfish   520 LTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRIENSVDRVYSLDEIRRYLLFARQFKPKI 584

  Fly   579 SQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRL 643
            |:|:...:||.|..|||||.....:|.||||||||||:|||||:||::.|.:.|..:||||||||
Zfish   585 SKESEEFIVEQYKRLRQRDGSGVTKSAWRITVRQLESLIRLSESMARMHCCDEVQPKHVKEAFRL 649

  Fly   644 LNKSIIRVEQPDIHLDDDE-------------GLDMDDGIQHDIDMENNGAAANVDENNGMD-TS 694
            |||||||||.||::||.:|             |.|:.:|:...::.|.||.    :..||:: ..
Zfish   650 LNKSIIRVETPDVNLDQEEEEAMEEEEDNQMNGHDVPNGVNGAVNGEVNGH----EHTNGINGHG 710

  Fly   695 ASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESED 759
            .:|...|....|||.:||.:|.:||||:|    |.|.:.::..:|:|.||.|||:::..:|:||.
Zfish   711 VNGETAKPSLRLSFAEYKRISNLLVLHLR----RAEEDEDEAALKKSEVVNWYLKEIESEIDSEM 771

  Fly   760 ELISRKNLIEKLIDRLIYHDQVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVVE 817
            ||||:|.:|||:|.||:::|.::|.||.|.||...:..:...:|:|..|||:|||..|
Zfish   772 ELISKKTMIEKVIYRLVHYDYILIELKQSGLKGSAESSETESQEEDVTLVVNPNYTFE 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	44/84 (52%)
		MCM	113..649	CDD:214631	387/537 (72%)
		MCM6_C	702..816	CDD:375690	49/113 (43%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	60/109 (55%)
		MCM	117..655	CDD:214631	387/537 (72%)
		P-loop_NTPase	<445..532	CDD:304359	74/86 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595576
Domainoid	1	1.000	380	1.000	Domainoid score	I802
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4322
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I285
OMA	1	1.010	-	-		QHG53901
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	1	1.000	-	-		otm24257
orthoMCL	1	0.900	-	-		OOG6_101983
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R696
SonicParanoid	1	1.000	-	-		X2150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800