DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm6l

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001020704.1	Gene:	mcm6l / 564982	ZFINID:	ZDB-GENE-050913-141	Length:	824	Species:	Danio rerio

Alignment Length:	818	Identity:	507/818 - (61%)
Similarity:	635/818 - (77%)	Gaps:	15/818 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRVKDEVGIRAQKLFQDFLEEFKE-DGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAII 74
            :.|:||:..:.||||.:|||||:: :|:..|...|..|..|:|.||.|||.::|.|:|.|||.|.
Zfish    10 VHVRDELSEKCQKLFLEFLEEFQDKNGDALYLSDAQELIRPERNTLTVSFSNIEHYNQQLATTIQ 74

  Fly    75 EEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTH 139
            ||||.:|||||::|.::.:|...:...|:.||||:|.|:|.|:|:|:|.:||||:||||||||||
Zfish    75 EEYYRVYPFLCRAVRHFARDHGNIPPSKEFYVAFSEFPSRQKIRELSTVRIGTLLRISGQVVRTH 139

  Fly   140 PVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQE 204
            |||||||||.|:|||||:.|::||||||:|.||||:||||:||:|||||..||.|:||||.||||
Zfish   140 PVHPELVSGTFLCLDCQSVIKDVEQQFKYTQPTICKNPVCANRRRFMLDTNKSRFVDFQKGRIQE 204

  Fly   205 TQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEG 269
            ||||||||.|||:||:|||:|.|||.|||||.||||||:||||||.:|..|||||.|||....||
Zfish   205 TQAELPRGSIPRSVEVILRAEAVETAQAGDRCDFTGTLVVVPDVSAMALAGTRAETSSRVTGKEG 269

  Fly   270 M--DGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEM 332
            .  ||:.||||||:|||:||:||||..|..|..||||.:|...:.|||.:|.|||..||.|::||
Zfish   270 FETDGIQGLKALGVRELSYRLAFLANYVAPTNPRFGGKELRQEDQTAESVKNQMTVLEWEKVFEM 334

  Fly   333 SKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQF 397
            |:|:|||.||.:||||:|:||||:||||||..||||||||.|.|||||||||||||||||:||||
Zfish   335 SQDKNLYHNLCTSLFPTIHGNDEIKRGILLMLFGGVAKTTMEGTSLRGDINVCIVGDPSTSKSQF 399

  Fly   398 LKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQ 462
            ||.|.||:|||:|||||||||||||||||:||||.:||||||||||||||:||||||||||.:||
Zfish   400 LKHVEDFAPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQ 464

  Fly   463 VAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFI 527
            ||||||||||||||.:|||:||||||||||||||||:|||:|:|||:||:.:|||||||||||||
Zfish   465 VAIHEAMEQQTISITKAGVKATLNARTSILAAANPIDGRYNRAKSLKQNVNMSAPIMSRFDLFFI 529

  Fly   528 LVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGH 592
            ||||||||.||||||:|||||:...|||||.|:.:|:.||:.|||||:|.|:.||...:|:.|..
Zfish   530 LVDECNEVTDYAIARRIVDLHARNVESVERVYSTDEIQRYILFARQFQPKITVEAQEFVVDQYKR 594

  Fly   593 LRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIH 657
            |||||.|.:.:|.|||||||||||:||||.||:|.||:.|..:||||||||||||||||:.|||:
Zfish   595 LRQRDGGGTTKSAWRITVRQLESMLRLSEGMARLYCSDEVQPKHVKEAFRLLNKSIIRVDSPDIN 659

  Fly   658 LD---DDEGL-DMDDGIQHDIDMEN----NGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNL 714
            .|   |::.: |.::....:.:.:|    ||.|....|.:..:.....|..|....:||.:||.:
Zfish   660 FDQEHDEDNINDQNELFGKETEGQNGGDVNGHAVEDMETDQTEKPEKPAAAKPALRMSFAEYKRV 724

  Fly   715 STMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHD 779
            |.:|||||:..|...|    |:.:|:|.::.|||:::..:|:||.||:::|||||:::.|||..|
Zfish   725 SNLLVLHMQKMEQLDE----DSSLKKSELINWYLKEIESEIDSEAELVAKKNLIERVLYRLINFD 785

  Fly   780 QVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVVE 817
            .:||.|..:.||...:..::.|.||||.|||.|||::|
Zfish   786 HIIIELTKTGLKKISEDGEEPVSEDDPFLVVDPNYILE 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	39/84 (46%)
		MCM	113..649	CDD:214631	393/537 (73%)
		MCM6_C	702..816	CDD:375690	48/113 (42%)
mcm6l	NP_001020704.1	MCM_N	23..133	CDD:291233	54/109 (50%)
		MCM	116..651	CDD:214631	392/534 (73%)
		P-loop_NTPase	<441..528	CDD:304359	73/86 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595577
Domainoid	1	1.000	380	1.000	Domainoid score	I802
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I285
OMA	1	1.010	-	-		QHG53901
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	1	1.000	-	-		otm24257
orthoMCL	1	0.900	-	-		OOG6_101983
Panther	1	1.100	-	-	O	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770