DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm9

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001333089.1	Gene:	mcm9 / 555610	ZFINID:	ZDB-GENE-041014-310	Length:	1135	Species:	Danio rerio

Alignment Length:	775	Identity:	233/775 - (30%)
Similarity:	356/775 - (45%)	Gaps:	169/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QVGQLRVKD---EVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQN 68
            |:.|...:|   .|.:.|..||:|.:|.    ||.....|:..|...|...            |.
Zfish    31 QILQENTEDLHYPVVVNAMTLFEDNMEV----GECFNAFPSKVLPIFDNAL------------QR 79

  Fly    69 LATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVP-----TRH---KVRDLTTSKI 125
            .|.||           .||.|:..:|...||  .:.:|..:.:|     ||.   |.||     :
Zfish    80 AAQAI-----------SQSSSSSPQDTFRLK--HNMHVRISGLPVCPELTRDHIPKARD-----V 126

  Fly   126 GTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNV-------EQQFKFTNPTICRNPV-CSNR 182
            |..:.::|.|:||...........:||..|    |:|       ||.:.||.||.|.:.. |.:.
Zfish   127 GHFLSVTGTVIRTSVTKVLEYERDYMCNKC----RHVFSVQASFEQFYTFTPPTSCPSEEGCGSF 187

  Fly   183 KRFML---DVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIV 244
            |...|   |...:...|:|:|:|||...:|..|.|||::.|||..:||::.::||
Zfish   188 KFTCLSGSDAPPAACKDYQEIKIQEQVQKLSVGSIPRSMLIILEDDLVDSCKSGD---------- 242

  Fly   245 VPDVSVLAGVGTRAENSSRHKPGEGM------DGVTGLKALGMRELNYRMAFLACSVQATTARFG 303
              |::|...|      ..|.||   |      |....||| ...|:|        :.|:|||
Zfish   243 --DITVYGVV------CQRWKP---MFQDCRCDVEIVLKA-NYIEVN--------NEQSTTA--- 284

  Fly   304 GTDLPMSEVTAEDMKKQMTDAEW--HKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFG 366
                    :..||::|:..:. |  || ::....||   .::.||.|.::|...||..:.:...|
Zfish   285 --------LVLEDIQKEFEEF-WDSHK-HDPIAGRN---EILMSLCPQVFGMYVVKLAVAMVLAG 336

  Fly   367 GVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEES 431
            ||.:.....|.:||:.::.:||||.|.||||||..:..:||::.|:|..|:.||||.|.|:|  |
Zfish   337 GVQRIDASGTKVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTNAGLTVAAVKD--S 399

  Fly   432 FDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAAN 496
            .::.:|||||:|:|.|:||||||:.:.:.|:.:|||||||||||:|:||:...|:.||:||||.|
Zfish   400 GEWHLEAGALVLSDGGLCCIDEFNSIKEHDRTSIHEAMEQQTISVAKAGMVCKLDTRTTILAATN 464

  Fly   497 PINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTR 561
            | .|:||.:.|:..|:.|::|::|||||..:|:|..|...|..|:..|:.......||: ..::.
Zfish   465 P-KGQYDPNVSVSVNVALASPLLSRFDLVLVLLDTKNPDWDKIISSFILQNKGAPSESL-CLWSM 527

  Fly   562 EEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKL 626
            |::..|....:..||.|:.||..:|...|...||.|:    |:..|.|:|.|||:.||:||.|:|
Zfish   528 EKMRAYFCLIKTLKPRITPEANTILSRYYQLQRQSDS----RNAARTTIRMLESLSRLAEAHARL 588

  Fly   627 ------------------ECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDD--------EGLD 665
                              |||       ::....|.|.:.:....||...:..        |.|.
Zfish   589 MFRETVTVEDAVVVVSVMECS-------MQGGALLGNVNALHTSFPDEPCEQYKTQCEIVLERLG 646

  Fly   666 MDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAE 725
            :.|.:|.::           ...:|:.....|:   .|...|..:::|.:|....|...|
Zfish   647 LSDLLQREL-----------QRLSGLQNGRPGS---PKSPQSHSEHRNENTTSTNHSNQE 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	19/83 (23%)
		MCM	113..649	CDD:214631	193/575 (34%)
		MCM6_C	702..816	CDD:375690	6/24 (25%)
mcm9	NP_001333089.1	Mcm2	23..588	CDD:224162	213/648 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820