Protein Alignment Mcm6 and mcm5

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001017327.2
• Gene: mcm5 / 550081
• XenbaseID: XB-GENE-985665
• Length: 735
• Species: Xenopus tropicalis
• Alignment Length: 679
• Identity: 212/679 - (31%)
• Similarity: 339/679 - (49%)
• Gaps: 82/679 - (12%)

  Fly     2 DVADAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGE-----IKYTRPAASLESPDRCTLEVSFED 61
            |...|:..||:          |.|::||.:::...:     .||........:.....:||..||
 Frog    23 DDGQAKKSQLK----------KRFREFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMED 77

  Fly    62 VEKYDQNLATAIIEEYYHIYPF----LCQSVSNYVKDRI------GLKTQKDCYVAFTEVPTRHK 116
            :..:|::||     :|.:..|.    |.:..:..|.|.:      |.:|.::..|..........
 Frog    78 LASFDEDLA-----DYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEETIQEIQVMLRSDANPAN 137

  Fly   117 VRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQ---FKFTNPTICR--- 175
            :|.|.:.::..|::|.|.::....|..:.......|..|:..|.|:..:   ..:..|..|.
 Frog   138 IRSLKSEQMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIAVRPGLEGYAMPRKCNTEQ 202

  Fly   176 --NPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDF 238
              .|.|.....|::. :|...:|||.:::||:...:|.|.:||.:::.....|.:.|..|:|
 Frog   203 AGRPKCPLDPYFIIP-DKCKCVDFQTLKLQESPDAVPHGELPRHMQLYCDRYLCDKVVPGNR--- 263

  Fly   239 TGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFG 303
                     |:::.....|....:..|   |.|.|    .:|:|....|:..:....:.|.....
 Frog   264 ---------VTIMGIYSIRKSGKTSTK---GRDRV----GVGIRSSYIRVVGIQVDTEGTGRSAA 312

  Fly   304 GTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGV 368
            |...|..|   |:.::            :|...::|:.:..|:.|||||:.::|:.|....|||.
 Frog   313 GAITPQEE---EEFRR------------LSAKPDIYETVAKSIAPSIYGSSDIKKAIACLLFGGS 362

  Fly   369 AKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFD 433
            .|...:..:.|||:|:.::|||.|||||.||.|...||..:|||||.||||||||:|:||..|.:
 Frog   363 RKRLPDGLTRRGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVMRDPVSRN 427

  Fly   434 FVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPI 498
            |::|.||::|||.|:.||||||||.:.|:|||||||||||||||:||:..|||:|.|:|||||.:
 Frog   428 FIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSV 492

  Fly   499 NGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNI---EESVERAYT 560
            .||:|.:|. ::||.....|:||||:.||:.||.||..|..:|:.::::|.:.   ..|||....
 Frog   493 YGRWDDTKG-EENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAKHVMNVHLSARTQSSSVEGEID 556

  Fly   561 REEVLRYVTFAR-QFKPVISQEAGHMLVENY----GHLRQRDTGTSGRSTWRITVRQLESMIRLS 620
            ...:.:|:.:.| :..|.:|.|:...|...|    ...|..:..|..||:..|||||||:::|:|
 Frog   557 LNTLKKYIAYCRAKCGPRLSAESAEKLKNRYILMRSGARDHERETEKRSSIPITVRQLEAIVRIS 621

  Fly   621 EAMAKLECSNRVLERHVKEAFRLLNKSII 649
            |::.|::......|..|:||.||...|.:
 Frog   622 ESLGKMKLQPFATETDVEEALRLFQVSTL 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	21/101 (21%)
		MCM	113..649	CDD:475121	187/551 (34%)
		MCM6_C	702..816	CDD:465688
mcm5	NP_001017327.2	MCM_N	33..131	CDD:464206	21/112 (19%)
		MCM	134..650	CDD:214631	187/551 (34%)
		Arginine finger	513..516		2/2 (100%)