DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm4

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001005655.1	Gene:	mcm4 / 448137	XenbaseID:	XB-GENE-1011481	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	756	Identity:	240/756 - (31%)
Similarity:	366/756 - (48%)	Gaps:	111/756 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FQDFLEEF-----KED-------GEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAII--- 74
            ||.|::.|     ||:       .|..|.:....:.......|.|..:.:..:||:|...::
Frog   166 FQRFVQRFIDPLAKEEENVGLDLNEPIYMQRLEEINVVGEPFLNVDCDHLRSFDQDLYRQLVCYP 230

  Fly    75 ------------EEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGT 127
                        |.::..||.........|:....|||:              .:|.|....|..
Frog   231 QEVIPTFDMAANEIFFERYPDSILEHQIQVRPYNALKTR--------------NMRSLNPEDIDQ 281

  Fly   128 LIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKS 192
            ||.|||.|:||..:.||:....|.|..|....|....:.:.:.|::|::  |:......|...:|
Frog   282 LITISGMVIRTSQIIPEMQEAFFKCQVCAFTTRVEIDRGRISEPSVCKH--CNTTHSMALIHNRS 344

  Fly   193 LFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTR 257
            :|.|.|.|::||:..::|.|..|....:...::||:.||.|||.:.||....||     ..|..|
Frog   345 MFSDKQMIKLQESPEDMPAGQTPHTTILYGHNDLVDKVQPGDRVNVTGIYRAVP-----IRVNPR 404

  Fly   258 AENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQM- 321
            ..|            |..:....:..::||        :....|..|.|        ||.:::|
Frog   405 VRN------------VKSVYKTHIDVIHYR--------KTDAKRLHGID--------EDTEQKMF 441

  Fly   322 TDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAK--TTTEKTSLRGDINV 384
            |:.....:.|::...::|:.|.|:|.||||.::::|:|||||.|||..|  :.|.:...|.::|:
Frog   442 TEERVAMLKELAAKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNI 506

  Fly   385 CIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGIC 449
            .:.|||.|:|||.|:.|.:..||..|||||.|||.||||.|::|.|:...|::.|||:|:|||||
Frog   507 LLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGIC 571

  Fly   450 CIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQL 514
            ||||||||::..:..:||.|||||:|||:||:...||||||:||||||:..:::..|:..:||||
Frog   572 CIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQL 636

  Fly   515 SAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLR-YVTFARQF-KPV 577
            ...::|||||.|:::|..:|..|..:|..:|.|:...||.::..:....||: |:.:||.: .|.
Frog   637 PHTLLSRFDLIFLMLDPQDETYDRRLAHHLVALYYQSEEQMKEEHLDMAVLKDYIAYARTYVNPR 701

  Fly   578 ISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFR 642
            :.:||...|:|.|..:|:..   |||.......|||||:||||||.||:..|::|....|:||.|
Frog   702 LGEEASQALIEAYVDMRKIG---SGRGMVSAYPRQLESLIRLSEAHAKVRFSSKVETIDVEEAKR 763

  Fly   643 LLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANV-DENNGMDTSASGAVQKK---- 702
            |..:::           .....|...||. ||.:...|.:|.. .....:.......:|.|
Frog   764 LHREAL-----------KQSATDPRTGIV-DISILTTGMSATARKRKEELAQVLKKLIQSKGKTP 816

  Fly   703 --KFTLSFEDYKNLSTMLV--------LHMRAEEARCEVEG 733
              |:...|||.:..|...|        ||..|:|....|.|
Frog   817 ALKYQQLFEDLRGQSDAAVTKDMFDEALHALADEDYLTVTG 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	20/110 (18%)
		MCM	113..649	CDD:214631	199/540 (37%)
		MCM6_C	702..816	CDD:375690	13/46 (28%)
mcm4	NP_001005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121
		PHA03307	<3..>122	CDD:223039
		MCM_N	166..264	CDD:379644	17/97 (18%)
		MCM	267..770	CDD:214631	201/565 (36%)
		Arginine finger	642..645		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920