Protein Alignment Mcm6 and MCM6

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_005906.2
• Gene: MCM6 / 4175
• HGNCID: 6949
• Length: 821
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 520/831 - (62%)
• Similarity: 647/831 - (77%)
• Gaps: 25/831 - (3%)

  Fly     1 MDV-ADAQVG----QLRVKDEVGIRAQKLFQDFLEEFK-EDGEIKYTRPAASLESPDRCTLEVSF 59
            ||: |.|:.|    .|.|:|||..:.||||.||||||: .||||||.:.|..|..|:|.||.|||
Human     1 MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSF 65

  Fly    60 EDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSK 124
            .|:|:::|.|:|.|.||:|.:||:||:::..:||||..:...||.||||.::|||||:|:||:|:
Human    66 VDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSR 130

  Fly   125 IGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDV 189
            ||.|.|||||||||||||||||||.|:||||||.||:||||||:|.|.|||||||:||:||:||.
Human   131 IGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDT 195

  Fly   190 EKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGV 254
            .||.|:||||:||||||||||||.|||::|:|||:|.||:.||||:.|||||||||||||.|:..
Human   196 NKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTP 260

  Fly   255 GTRAENSSRHKPGEG--MDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDM 317
            |.|||.:||....:|  .:|:.||:|||:|:|:||:.||||.|..|..||||.:|...|.|||.:
Human   261 GARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESI 325

  Fly   318 KKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDI 382
            |.|||..||.|::|||:|:|||.||.:||||:|:||||||||:||..||||.|||.|.|||||||
Human   326 KNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDI 390

  Fly   383 NVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNG 447
            |||||||||||||||||.|.:|||||:||||||||||||||||||||||.:||||||||||||||
Human   391 NVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNG 455

  Fly   448 ICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNI 512
            :||||||||||.|||||||||||||||||.:|||:||||||||||||||||:|.|||||||:|||
Human   456 VCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNI 520

  Fly   513 QLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFKPV 577
            .||||||||||||||||||||||.||||||:||||||.||||::|.|:.:::.||:.|||||||.
Human   521 NLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPK 585

  Fly   578 ISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFR 642
            ||:|:...:||.|.||||||.....:|:|||||||||||||||||||::.|.:.|..:|||||||
Human   586 ISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFR 650

  Fly   643 LLNKSIIRVEQPDIHLDDDEGLDMD-----DGIQHDIDMENNGAAANVDENNGMDTSAS-GAVQK 701
            ||||||||||.||::||.:|.:.|:     .||....|     :.|.|:..||.:...: .:..|
Human   651 LLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHAD-----SPAPVNGINGYNEDINQESAPK 710

  Fly   702 KKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDELISRKN 766
            ....|.|.:|..:|.::|||:|    :.|.|.:::.:|||.:|.|||:::..:|:||:|||::|.
Human   711 ASLRLGFSEYCRISNLIVLHLR----KVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKR 771

  Fly   767 LIEKLIDRLIYHDQVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVVE 817
            :|||:|.||.::|.|:|.|..:.||...:..:.:  |:||.|||:|||::|
Human   772 IIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESY--EEDPYLVVNPNYLLE 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	47/87 (54%)
		MCM	113..649	CDD:475121	396/537 (74%)
		MCM6_C	702..816	CDD:465688	45/113 (40%)
MCM6	NP_005906.2	MCM_N	27..116	CDD:464206	48/88 (55%)
		MCM	119..657	CDD:475121	396/537 (74%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:465688	43/109 (39%)