DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and MCM6

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_005906.2	Gene:	MCM6 / 4175	HGNCID:	6949	Length:	821	Species:	Homo sapiens

Alignment Length:	831	Identity:	520/831 - (62%)
Similarity:	647/831 - (77%)	Gaps:	25/831 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDV-ADAQVG----QLRVKDEVGIRAQKLFQDFLEEFK-EDGEIKYTRPAASLESPDRCTLEVSF 59
            ||: |.|:.|    .|.|:|||..:.||||.||||||: .||||||.:.|..|..|:|.||.|||
Human     1 MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSF 65

  Fly    60 EDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSK 124
            .|:|:::|.|:|.|.||:|.:||:||:::..:||||..:...||.||||.::|||||:|:||:|:
Human    66 VDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSR 130

  Fly   125 IGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDV 189
            ||.|.|||||||||||||||||||.|:||||||.||:||||||:|.|.|||||||:||:||:||.
Human   131 IGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDT 195

  Fly   190 EKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGV 254
            .||.|:||||:||||||||||||.|||::|:|||:|.||:.||||:.|||||||||||||.|:..
Human   196 NKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTP 260

  Fly   255 GTRAENSSRHKPGEG--MDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDM 317
            |.|||.:||....:|  .:|:.||:|||:|:|:||:.||||.|..|..||||.:|...|.|||.:
Human   261 GARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESI 325

  Fly   318 KKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDI 382
            |.|||..||.|::|||:|:|||.||.:||||:|:||||||||:||..||||.|||.|.|||||||
Human   326 KNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDI 390

  Fly   383 NVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNG 447
            |||||||||||||||||.|.:|||||:||||||||||||||||||||||.:||||||||||||||
Human   391 NVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNG 455

  Fly   448 ICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNI 512
            :||||||||||.|||||||||||||||||.:|||:||||||||||||||||:|.|||||||:|||
Human   456 VCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNI 520

  Fly   513 QLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFKPV 577
            .||||||||||||||||||||||.||||||:||||||.||||::|.|:.:::.||:.|||||||.
Human   521 NLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPK 585

  Fly   578 ISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFR 642
            ||:|:...:||.|.||||||.....:|:|||||||||||||||||||::.|.:.|..:|||||||
Human   586 ISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFR 650

  Fly   643 LLNKSIIRVEQPDIHLDDDEGLDMD-----DGIQHDIDMENNGAAANVDENNGMDTSAS-GAVQK 701
            ||||||||||.||::||.:|.:.|:     .||....|     :.|.|:..||.:...: .:..|
Human   651 LLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHAD-----SPAPVNGINGYNEDINQESAPK 710

  Fly   702 KKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDELISRKN 766
            ....|.|.:|..:|.::|||:|    :.|.|.:::.:|||.:|.|||:::..:|:||:|||::|.
Human   711 ASLRLGFSEYCRISNLIVLHLR----KVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKR 771

  Fly   767 LIEKLIDRLIYHDQVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVVE 817
            :|||:|.||.::|.|:|.|..:.||...:..:.:  |:||.|||:|||::|
Human   772 IIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESY--EEDPYLVVNPNYLLE 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	44/84 (52%)
		MCM	113..649	CDD:214631	396/537 (74%)
		MCM6_C	702..816	CDD:375690	45/113 (40%)
MCM6	NP_005906.2	MCM_N	27..114	CDD:405270	46/86 (53%)
		MCM	119..657	CDD:214631	396/537 (74%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:408078	43/109 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159412
Domainoid	1	1.000	383	1.000	Domainoid score	I831
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4322
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I293
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53901
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	1	1.000	-	-		oto91524
orthoMCL	1	0.900	-	-		OOG6_101983
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R696
SonicParanoid	1	1.000	-	-		X2150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800