DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm6 and MCM4

DIOPT Version :9

Sequence 1:NP_511065.1 Gene:Mcm6 / 31603 FlyBaseID:FBgn0025815 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_005905.2 Gene:MCM4 / 4173 HGNCID:6947 Length:863 Species:Homo sapiens


Alignment Length:821 Identity:254/821 - (30%)
Similarity:389/821 - (47%) Gaps:134/821 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ADAQVGQLRV--KDEVGIRA-QKLFQDFLEEF-----KEDGEI-------KYTRPAASLESPDRC 53
            ::..:||..|  ..:|.:.| ::.||.||:.|     ||:..:       .|.:....:......
Human   142 SEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEP 206

  Fly    54 TLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRI---------------GLKTQKD 103
            .|.|:.|.::.:|:||...:|.....:.|....:|:....||.               .|||:  
Human   207 FLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTK-- 269

  Fly   104 CYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKF 168
                        .:|:|....|..||.|||.|:||..:.||:....|.|..|....|....:.:.
Human   270 ------------NMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRI 322

  Fly   169 TNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAG 233
            ..|::|..  |.......|...:|||.|.|.|::||:..::|.|..|..|.:...::||:.||.|
Human   323 AEPSVCGR--CHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPG 385

  Fly   234 DRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQAT 298
            ||.:.||....||     ..|..|..|            |..:....:..::||        :..
Human   386 DRVNVTGIYRAVP-----IRVNPRVSN------------VKSVYKTHIDVIHYR--------KTD 425

  Fly   299 TARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQ 363
            ..|..|.|       .|..:|..::.....:.|:|:..::|:.|.|:|.||||.::::|:|||||
Human   426 AKRLHGLD-------EEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQ 483

  Fly   364 QFGGVAK--TTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVV 426
            .|||..|  :.|.:...|.:||:.:.|||.|:|||.|:.|.:..||..|||||.|||.||||.|:
Human   484 LFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVM 548

  Fly   427 RDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSI 491
            :|.|:...|::.|||:|:|||||||||||||::..:..:||.|||||:|||:||:...||||||:
Human   549 KDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSV 613

  Fly   492 LAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVE 556
            |||||||..:::..|:..:||||...::|||||.|:|:|..:|..|..:|..:|.|:...||..|
Human   614 LAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAE 678

  Fly   557 RAYTREEVLR-YVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRL 619
            .......||: |:.:|.. ..|.:|:||...|:|.|..:|:  .|:| |.......|||||:|||
Human   679 EELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRK--IGSS-RGMVSAYPRQLESLIRL 740

  Fly   620 SEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAAN 684
            :||.||:..||:|....|:||.||..:::           .....|...||. ||.:        
Human   741 AEAHAKVRLSNKVEAIDVEEAKRLHREAL-----------KQSATDPRTGIV-DISI-------- 785

  Fly   685 VDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLE 749
                  :.|..|...:|:|     |:.......|:|.          :|....:|        .:
Human   786 ------LTTGMSATSRKRK-----EELAEALKKLILS----------KGKTPALK--------YQ 821

  Fly   750 QVADQIESEDELISRKNLIEKLIDRLIYHDQVIIPLKTSTL 790
            |:.:.|..:.::...|::.|:.:..|...|.:.:..||..|
Human   822 QLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRL 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm6NP_511065.1 MCM_N 25..109 CDD:379644 22/110 (20%)
MCM 113..649 CDD:214631 204/539 (38%)
MCM6_C 702..816 CDD:375690 15/89 (17%)
MCM4NP_005905.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..126
MCM_N 163..263 CDD:405270 19/99 (19%)
MCM 267..770 CDD:214631 206/564 (37%)
Arginine finger 642..645 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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