Protein Alignment Mcm6 and MCM3

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001353298.1
• Gene: MCM3 / 4172
• HGNCID: 6945
• Length: 833
• Species: Homo sapiens
• Alignment Length: 733
• Identity: 221/733 - (30%)
• Similarity: 359/733 - (48%)
• Gaps: 120/733 - (16%)

  Fly    13 VKDEVGIR-AQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEE 76
            |.|:|.:| ||:.:.|||::.::.|  .|......|.|.::..|.|:..|:.:.::..|..::..
Human     6 VLDDVELREAQRDYLDFLDDEEDQG--IYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNN 68

  Fly    77 YYHIYPFLCQSVSNYVK--DRIGLKTQKDCYVAFT-EVPTRH-KVRDLTTSKIGTLIRISGQVVR 137
            .:.......:::.::|.  |....|..::.||... ...::| ..|.||:..:..::.:.|.|.:
Human    69 AFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTK 133

  Fly   138 THPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCS-----NRKRFMLDVE--KSLFL 195
            ...|.|::|..|..   |....:.:|:::.... |:...|..|     :.:...|:.|  .|::.
Human   134 CSLVRPKVVRSVHY---CPATKKTIERRYSDLT-TLVAFPSSSVYPTKDEENNPLETEYGLSVYK 194

  Fly   196 DFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAEN 260
            |.|.|.|||...:.|.|.:||:|::||..:||:..:.|||....||...:|
Human   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-------------- 245

  Fly   261 SSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAE 325
                    |..|       |.....:|...:||:|:..:     .|...| .:|||:.|
Human   246 --------GKKG-------GYTSGTFRTVLIACNVKQMS-----KDAQPS-FSAEDIAK------ 283

  Fly   326 WHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDP 390
             .|.:..::.::::..|..||.|||:|:|.||:.||....|||.:.....:.:|||||:.::|||
Human   284 -IKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDP 347

  Fly   391 STAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFD 455
            |.||||.|:.|...:||||.|:|:.||..||||||..|:|:.:..:||||::|||.|:.||||||
Human   348 SVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFD 412

  Fly   456 KMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMS 520
            ||...|:.||||.|||..::||:||:.|.||||.|:||||||:.||||:.|:..:||.|...::|
Human   413 KMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLS 477

  Fly   521 RFDLFFILVDECN-----EVVDYAIA--------------------------------------R 542
            ||||.||::|:.:     |:.|:.:.                                      .
Human   478 RFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDT 542

  Fly   543 KIVDLHSNI--------EESVERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTG 599
            :|.:.|.|:        |:.|..|:.:    :|:..|:..|||::||:...:.|.|..||.:|:.
Human   543 QIYEKHDNLLHGTKKKKEKMVSAAFMK----KYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSM 603

  Fly   600 TSGRS-TWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLN----KSIIRVEQPDIHLD 659
            :|..: |..:|.|.||::|||:.|.||...|..|..:..:||..|:.    |.::..|:......
Human   604 SSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRS 668

  Fly   660 DDEGLDMDDGIQHDIDME 677
            :||....|:..:...|.|
Human   669 EDESETEDEEEKSQEDQE 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	17/88 (19%)
		MCM	113..649	CDD:475121	193/599 (32%)
		MCM6_C	702..816	CDD:465688
MCM3	NP_001353298.1	MCM_N	16..104	CDD:464206	17/89 (19%)
		MCM	109..654	CDD:214631	192/594 (32%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..739		5/25 (20%)