DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm6 and MCM2

DIOPT Version :10

Sequence 1:NP_511065.1 Gene:Mcm6 / 31603 FlyBaseID:FBgn0025815 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_004517.2 Gene:MCM2 / 4171 HGNCID:6944 Length:904 Species:Homo sapiens


Alignment Length:690 Identity:218/690 - (31%)
Similarity:353/690 - (51%) Gaps:113/690 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VKDEVGIRAQKL-----FQDFLEEFKED-GEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLA- 70
            |::.|.:...:|     |::||....:. |...:....:.:...:|.:|.|::||:...:..|| 
Human   182 VREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAY 246

  Fly    71 --------------TAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLT 121
                          .|.:|....:|| ....::|::            :|..:.:|...::|.|.
Human   247 FLPEAPAELLQIFDEAALEVVLAMYP-KYDRITNHI------------HVRISHLPLVEELRSLR 298

  Fly   122 TSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEI----RNVEQQFKFTNPTICRNPVCSNR 182
            ...:..|||.||.|.....|.|:|....:.|..|...:    ::..|:.|   |..|  |.|.:.
Human   299 QLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVK---PGSC--PECQSA 358

  Fly   183 KRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPD 247
            ..|.:::|::::.::|:|||||:..::..|.:||:.:.||.::||::.:.||..:.||..     
Human   359 GPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIY----- 418

  Fly   248 VSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAF--LACSVQATTARFGGTDLPMS 310
                            |...:|             .||....|  .|..:.|.........:.:.
Human   419 ----------------HNNYDG-------------SLNTANGFPVFATVILANHVAKKDNKVAVG 454

  Fly   311 EVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEK 375
            |:|.||:|         .|..:|||:.:.:.:.:|:.|||||::::|||:.|..|||..|....|
Human   455 ELTDEDVK---------MITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGK 510

  Fly   376 TSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGA 440
            ..:||||||.:.|||.||||||||.:...|.|||:|:|:.:||.||||.|.|...|.::.:||||
Human   511 HKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGA 575

  Fly   441 LMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRS 505
            |:|||.|:|.|||||||:.:|:.:||||||||:|||::||:..:|.||.:::||||||.||||.|
Human   576 LVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPS 640

  Fly   506 KSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLH-----SNIEE-------SVERA 558
            .:..:|:.|:.||:||||:..::.|..:.|.|..:||.:|..|     ||.||       :.|.|
Human   641 LTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPA 705

  Fly   559 YTR--------EEVL-RYVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQL 613
            ...        :||| :|:.:|:: ..|.::|.....:.:.|..||:....|   .:..||||.:
Human   706 MPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMAT---GSIPITVRHI 767

  Fly   614 ESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQ 653
            |||||::||.|::...:.|:|..|..|.|::.:|.|..::
Human   768 ESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm6NP_511065.1 MCM_N 22..109 CDD:464206 18/107 (17%)
MCM 113..649 CDD:475121 196/563 (35%)
MCM6_C 702..816 CDD:465688
MCM2NP_004517.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80
Interaction with KAT7. /evidence=ECO:0000250 2..257 14/74 (19%)
Interaction with DNJC9. /evidence=ECO:0000269|PubMed:33857403 61..130
MCM2_N 73..182 CDD:403724 218/690 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..167
MCM_N 197..287 CDD:464206 17/102 (17%)
MCM 291..803 CDD:214631 196/562 (35%)
Arginine finger 655..658 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..705 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

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