DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mei-218

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	123/756 - (16%)
Similarity:	235/756 - (31%)	Gaps:	262/756 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQ 86
            |.:.::|.|...|         .:|.::|::..  |.::..||..|..::..|....|:......
  Fly   479 QAVSREFTESLLE---------GSSGKTPEKEV--VPYQQQEKPRQVKSSPEIHASSHMRKLAMG 532

  Fly    87 SVSN------------YVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTH 139
            ||.|            ::..::...:|:.|...||        |.|...|
  Fly   533 SVLNSNAKEFHPTGESHLTHKVSRLSQRRCRQRFT--------RSLHAKK--------------- 574

  Fly   140 PVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQE 204
                                .|..:|  ..||.....|:          :|.:..:|.|...
  Fly   575 --------------------NNPREQ--LPNPDSAPEPI----------LEYTSEIDDQPCP--- 604

  Fly   205 TQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVL-AGVGTRAENSSRHKPGE 268
                 ||..:...:|.|:...::|....|:          :|.|... ...|....|||...|.|
  Fly   605 -----PRQTVDTPIEAIVPPAMIEVSATGN----------LPPVFYFDQQSGIIWSNSSPQIPVE 654

  Fly   269 GMDGVTGLKALGMRELNYRMAFLACSVQATT-----------------ARF-----GGTDL---- 307
                   :::..:.:..:|:|.|.|:...||                 :|.     |.|.|
  Fly   655 -------IQSNSVSQSVFRLASLPCTGVGTTNMDIFTSSPPPIQHMSSSRLPSSISGPTQLSHTL 712

  Fly   308 ----------------------------PMSEVTAEDMKKQMTDAEW------------------ 326
                                        |:.::..|:.:.:..|.||
  Fly   713 SSPPVENQHQQHLWESCIHQDEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIEPPSFQSENQVV 777

  Fly   327 ---------------------HKIYEM-----------------SKDRNLYQNLISSLFPS---I 350
                                 |.|:..                 |..:.|: :||||.:..   :
  Fly   778 ADEHGEENAYLAKDAGPPLERHMIFRAPSQHGQEYPKPDLNCVPSSIKKLH-HLISSQYSDYSFV 841

  Fly   351 YG-NDEVKRG-------ILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPR 407
            |. :.::.:.       :.|:.....:..:.|...:|..|::||:...|...::.|.:|...:||
  Fly   842 YALSAQISQDCVPMDCFVYLKMILLASIVSIESDEVRAPISLCIIATDSLMANRLLNKVGQLAPR 906

  Fly   408 AIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQ 472
            .:     .....||..........|:::: |..|:||..|:....:::::.:.....:.:.:|..
  Fly   907 FL-----GPHEYGLQPTFNALPTRFNWIV-ASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENG 965

  Fly   473 TISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLS--APIMSRFDLFFILVDECNEV 535
            .:.:.:..:...|.|  ::.....|.|       |..|.:.|:  .||   |.|...:..:.:.
  Fly   966 AVPVPQLHIDQPLKA--AVWTYWQPNN-------STNQTLALAKLCPI---FGLPIYMGAQASN- 1017

  Fly   536 VDYAIARKIVDLHSNIEESV----ERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQR 596
               ::...|:..| |.|..:    ..:...:::...:....|.|..::..|.|||.:.|...|:.
  Fly  1018 ---SLWNSIIQKH-NAEGQIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDGAQHMLQKYYVISRKE 1078

  Fly   597 DTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHV 637
            ........|: |.::|      |:|..|||.....|||..|
  Fly  1079 RPNVFSSKTY-IVLKQ------LAECFAKLALRLEVLESDV 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	16/95 (17%)
		MCM	113..649	CDD:214631	104/653 (16%)
		MCM6_C	702..816	CDD:375690
mei-218	NP_001027068.1	PTZ00112	122..>417	CDD:240274
mei-218	NP_001027068.1	MCM	<1023..1116	CDD:278895	24/98 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010