DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm4

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_944595.2	Gene:	mcm4 / 337598	ZFINID:	ZDB-GENE-030131-9544	Length:	845	Species:	Danio rerio

Alignment Length:	810	Identity:	249/810 - (30%)
Similarity:	385/810 - (47%)	Gaps:	127/810 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESP------DRCT------LEV 57
            |..||..:.|          ||.||::|.:....:.......|..|      |..:      |.|
Zfish   138 DVNVGTCKEK----------FQRFLQQFTDPDSREEENAGLDLNEPLYMQKLDEISVVGEPVLNV 192

  Fly    58 SFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYV-------AFTEVPTRH 115
            :...::.:|.:|...:|.....:.|....||:....||.     .|..:       .::.:.||:
Zfish   193 NCTHIQTFDADLYRQLICYPQEVIPTFDMSVNELFFDRF-----PDSVLEHQIQVRPYSAIKTRN 252

  Fly   116 KVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCS 180
             :|:|....|..||.|||.|:||..:.||:....|.|..|....|....:.:...|.:|||  |:
Zfish   253 -MRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEVDRGRIAEPAVCRN--CN 314

  Fly   181 NRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVV 245
            ......|...:|:|.|.|.|::||:..::|.|..|....:...::||:.||.|||.:.||.....
Zfish   315 TTHSMALVHNRSVFSDKQMIKLQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNITGIYRAA 379

  Fly   246 PDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMS 310
            |    :.....:::..|.:|        |.:.|:..|:.:.:             |..|.|
Zfish   380 P----MRLNPRQSQVKSVYK--------THIDAIHFRKTDEK-------------RLHGLD---- 415

  Fly   311 EVTAED-MKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAK--TT 372
                || .:|..|......:.|::...::|:.|.|:|.||||.::::|:|||||.|||..|  |.
Zfish   416 ----EDGEQKLFTKERVALLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQ 476

  Fly   373 TEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIE 437
            |.:.:.|.::|:.:.|||.|:|||.|:.|.:..||..|||||.|||.||||.|::|.|:...|::
Zfish   477 TGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQ 541

  Fly   438 AGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRY 502
            .|||:|:|||||||||||||....:..:||.|||||:|||:||:...|||||||||||||:..::
Zfish   542 TGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQW 606

  Fly   503 DRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLR- 566
            :..|:..:||||...::|||||.|:::|..:|..|..:|..:|.|:...||.:|..:....||:
Zfish   607 NPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQIEEEHLDMAVLKD 671

  Fly   567 YVTFAR-QFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSN 630
            |:.||| ...|.:|:||...|:|.|..:|:..   |||.......|||||:|||:||.||:..|.
Zfish   672 YIAFARTTVHPRLSEEASQALIEAYVDMRKIG---SGRGMVSAYPRQLESLIRLAEAHAKVRFSG 733

  Fly   631 RVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSA 695
            :|....|:||.||..:::           .....|...|.. ||.:              :.|..
Zfish   734 KVETIDVEEAKRLHREAL-----------KQSATDPRTGFV-DISI--------------LTTGM 772

  Fly   696 SGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDE 760
            |...:|:|     |:.......|:          :.:|....:|        .:|:.|.:..:.|
Zfish   773 SATARKRK-----EEVAQALKKLI----------QSKGKTPAMK--------YQQLFDDLRGQSE 814

  Fly   761 LISRKNLIEKLIDRLIYHDQVIIPLKTSTL 790
            ....|::.::.:..|...|.:.:..||..|
Zfish   815 AAITKDMFDEALRLLADEDYLTVTGKTVRL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	19/102 (19%)
		MCM	113..649	CDD:214631	205/540 (38%)
		MCM6_C	702..816	CDD:375690	14/89 (16%)
mcm4	NP_944595.2	MCM_N	147..269	CDD:291233	28/137 (20%)
		MCM	249..752	CDD:214631	205/552 (37%)
		P-loop_NTPase	487..626	CDD:304359	76/138 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820