DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and Mcm8

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001099984.1	Gene:	Mcm8 / 296178	RGDID:	1305218	Length:	830	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	240/819 - (29%)
Similarity:	368/819 - (44%)	Gaps:	200/819 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDEVGIRAQKLFQDFLEEFKEDGEIKYTRP---AASLESPDRCTL--------EVSFEDVEKYDQ 67
            |||:. |...:..|| :|..:|.||....|   .|..::|:: ||        :|..:|:|::..
  Rat   102 KDEIE-RKGSILVDF-KELTKDNEITNLIPDIENALRDAPEK-TLACMGLAIHQVLTKDLERHAA 163

  Fly    68 NLAT--------AIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSK 124
            .|..        ..:....|||    ..|.||                   .|..| ::::..:.
  Rat   164 ELQAQEGLCNGGGTMVNVPHIY----ARVYNY-------------------EPLTH-LKNIRATC 204

  Fly   125 IGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQF-----KFTNPTICRNPVCSNRKR 184
            .|..|.|.|.|||...:.|......|.|..| .||    |.|     |:..||.|..|.|  |.|
  Rat   205 YGKYISIRGTVVRVSNIKPLCTKMAFQCAAC-GEI----QSFPLPDGKYNLPTKCPVPAC--RGR 262

  Fly   185 FMLDVEKS---LFLDFQKIRIQETQAELPR--GCIPRAVEIILRSELVETVQAGDRYDFTGTLIV 244
            ....:..|   :.:|:|.|:|||..::..|  |.|||.:|..|..:||::...||....||.:.|
  Rat   263 SFTPLRSSPLTVTMDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKV 327

  Fly   245 VPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFL----ACSV------QATT 299
                       :.:|..||.|                   |.:..||    |.||      :|.|
  Rat   328 -----------SNSEEGSRSK-------------------NDKCMFLLYIEANSVSNSKGQKAQT 362

  Fly   300 ARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQ 364
            |..|.....:.|.:.:|:         :.|.|:..:.||.:.:::||.|.|:|::.||.|::|..
  Rat   363 AEDGCKHGTLMEFSLKDL---------YAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLMLAL 418

  Fly   365 FGGVAKTTTEKT--SLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVR 427
            |||..|...:|.  .:|||.:|.|||||...|||.|:...:.:||.:|..|..::::|||..:.:
  Rat   419 FGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTATSSGLTVTLSK 483

  Fly   428 DEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSIL 492
            |..|.||.:|||||:|.|.|||.|||||||..:.| |:.||||||:||:|:|||..:|.|||||:
  Rat   484 DSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSII 547

  Fly   493 AAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVER 557
            |||||:.|.|::::::.:|:::.:.::|||||.|||:|..||..|:.::..::.:.:..:.:|..
  Rat   548 AAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSS 612

  Fly   558 AYTREEVL--------------------------------------RYVTFARQF-KPVISQEAG 583
            | |...||                                      :|:.:|||: .|.:|.||.
  Rat   613 A-TVSRVLSQDSNTSVLEVVSEKPLSERLKVAPGEKTDPIPHQLLRKYIGYARQYVHPRLSTEAA 676

  Fly   584 HMLVENYGHLRQRD--TGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNK 646
            ..|.:.|..||::.  .|:|     .||.|||||:|||:||.|:||......:...::...::..
  Rat   677 QALQDFYLELRKQSQRVGSS-----PITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKH 736

  Fly   647 SIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKF-----TL 706
            |::     ..:.|:...||.:.. ||...|.|...|                   |:|     ::
  Rat   737 SML-----GTYSDEFGNLDFERS-QHGSGMSNRSTA-------------------KRFISALNSI 776

  Fly   707 SFEDYKNLSTMLVLHMRAEEARCEVEG--------NDTG 737
            :...|.|:.....|...|:|...:|..        ||.|
  Rat   777 AERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQG 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	21/102 (21%)
		MCM	113..649	CDD:214631	195/598 (33%)
		MCM6_C	702..816	CDD:375690	11/49 (22%)
Mcm8	NP_001099984.1	MCM_N	88..213	CDD:291233	30/137 (22%)
		Mcm2	129..827	CDD:224162	230/790 (29%)
		AAA	425..583	CDD:99707	76/158 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820