Protein Alignment Mcm6 and Mcmdc2

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_808390.2
• Gene: Mcmdc2 / 240697
• MGIID: 3045334
• Length: 681
• Species: Mus musculus
• Alignment Length: 630
• Identity: 126/630 - (20%)
• Similarity: 221/630 - (35%)
• Gaps: 187/630 - (29%)

  Fly    84 LCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHK--VRDLTTSKIGTLIRISGQVVRTH---PVHP 143
            ||:...||...|..:  .:...:|.|.: |::.  .|.|.:..:..|.: ..|.||.|   ....
Mouse   115 LCEFPLNYASQRFYM--MQGIVIAMTTI-TKYTQGARFLCSDGVCPLSK-GFQYVRVHVPGATES 175

  Fly   144 ELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDF------QKIRI 202
            ..|...|:|..|.:.::. :::|:....           |:.:..:...:|..|      |..|.
Mouse   176 ATVRNDFLCSLCSSSLQE-DRKFRVLGD-----------KQIVEIITTKMFHAFQGDSKNQPFRF 228

  Fly   203 QETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPG 267
            |             ::.|.||.|||..::.|:.|...|..:.|........|  .|.|.:.|
Mouse   229 Q-------------SLGIFLRDELVNKMKIGNEYKIIGIPVCVKTSQTALCV--EANNITPH--- 275

  Fly   268 EGMDGVTGLKALGMRELNYR-------------MAFLACSVQATTARFGGT------DLPMSEVT 313
                  |....||:.: |:|             .|.|| :|.|:.....||      .|.||.|.
Mouse   276 ------TAKVPLGISD-NFRRLLSLTSSSCWKFTAMLA-NVFASQIVAPGTYNLLKLCLLMSLVQ 332

  Fly   314 AEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSL 378
            ..|..::..|.  ..|..::.|..|...|::      :..:.|.|||...
Mouse   333 TRDCNREREDC--LDILVITSDTLLVDRLLN------FSMNLVSRGIRHP--------------- 374

  Fly   379 RGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALML 443
                 ||....|:.::::             |.:|..|                   |:||:.:|
Mouse   375 -----VCTEVFPTVSRNK-------------YGTGAVS-------------------IQAGSALL 402

  Fly   444 ADNGICCIDEF-----DKMDQRDQVAIHEAMEQQTISIARAGVR--------ATLNARTSILAAA 495
            |..|||.|.:.     ||::|     :..|:|.:::::...|.:        .|...:.|..:..
Mouse   403 AKGGICFIGDLTSHKKDKLEQ-----LQSALESRSVTVFIPGKKFGDDFDQQMTFPIQCSFWSFV 462

  Fly   496 NPINGRYDRSKSLQQNIQLSAPIMSRFDLFFI---------LVDECNEVVDYAIARKIVDLHSNI 551
                   |...|.::|:|.::.::.:.|...|         |:..|:|      |.....|...:
Mouse   463 -------DMDSSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSE------ASPCHPLLPTV 514

  Fly   552 EESVERA-------------YTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGR 603
            :.::::|             :|.|:..:.:.||:......|.||..| :..| :|..|...|...
Mouse   515 QHTLKKAVEPEGLLYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERM-IHGY-YLASRRIRTDSI 577

  Fly   604 STWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSI 648
            ...:::...|:.::.||||.|:|.....||......|..||..|:
Mouse   578 HGSKLSASALKYLVSLSEAHARLSLRTTVLREDALIAALLLEISL 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	6/24 (25%)
		MCM	113..649	CDD:475121	119/601 (20%)
		MCM6_C	702..816	CDD:465688
Mcmdc2	NP_808390.2	MCM	<395..621	CDD:475121	53/245 (22%)
		MCM_lid	<557..622	CDD:465534	19/66 (29%)