Protein Alignment Mcm6 and mcm2

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_775364.2
• Gene: mcm2 / 192338
• ZFINID: ZDB-GENE-020419-24
• Length: 889
• Species: Danio rerio
• Alignment Length: 680
• Identity: 220/680 - (32%)
• Similarity: 351/680 - (51%)
• Gaps: 96/680 - (14%)

  Fly    13 VKDEVGIRAQKL-----FQDFLE-EFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLAT 71
            |::.|.:.|.:|     |::||. ...|.|...:....:.:...::.:|.|::|::...:..||.
Zfish   170 VREWVSMAAPRLEIYHRFKNFLRTHVDEHGHNVFKERISDMCKENKESLLVNYEELASREHVLAY 234

  Fly    72 AIIE---EYYHIYPFLCQSV--SNYVK-DRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIR 130
            .:.|   |...|:....:.|  :.|.| |||.    .:.:|....:|...::|.|....:..|||
Zfish   235 FLPEAPAEMLKIFDEAAKEVVLAMYPKYDRIA----HEIHVRIGNLPLVEELRSLRQLHLNQLIR 295

  Fly   131 ISGQVVRTHPVHPELVSGVFMCLDCQTEI----RNVEQQFKFTNPTICRNPVCSNRKRFMLDVEK 191
            .||.|.....|.|:|....:.|..|...:    ::..|:.|   |..|  |.|.:...|.:::|:
Zfish   296 TSGVVTSCTGVLPQLGMVKYNCNKCNFILGPFFQSQNQEVK---PGSC--PECQSLGPFEINMEQ 355

  Fly   192 SLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGT 256
            :::.::|:|.|||:..::..|.:||:.:.||.::||:..:.||..:.||..
Zfish   356 TVYQNYQRITIQESPGKVAAGRLPRSKDAILLADLVDMCKPGDEIELTGIY-------------- 406

  Fly   257 RAENSSRHKPGEGMDGVTGLKALGMRELNYRMAF--LACSVQATTARFGGTDLPMSEVTAEDMKK 319
                   |...:|             .||....|  .|..:.|.........:.::|:|.||:|
Zfish   407 -------HNNYDG-------------SLNMANGFPVFATVILANHIARKDEGVAVAELTDEDVK- 450

  Fly   320 QMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINV 384
                    .|..:|||..:.:.:.:|:.||||.::::|||:.|..|||.||....|..:||||||
Zfish   451 --------AIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKNPGGKHKVRGDINV 507

  Fly   385 CIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGIC 449
            .:.|||.||||||||.|...:.||::|:|:.:||.||||.|.|...|.::.:|||||:|||.|:|
Zfish   508 LLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVC 572

  Fly   450 CIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQL 514
            .|||||||:.:|:.:||||||||:|||::||:..:|.||.:::||||||.||||.|.:..:|:.|
Zfish   573 LIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDL 637

  Fly   515 SAPIMSRFDLFFILVDECNEVVDYAIARKIVDLH-----SNIEESVERAYTREEVL--------- 565
            :.||:||||:..::.|..:.|.|..:||.:|..|     ||.|..|  |...|.||
Zfish   638 TEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIKHHPSNKEGGV--AGLEEVVLPNTFDVPPI 700

  Fly   566 ------RYVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAM 623
                  :|:.:|:: .:|.::|.....:...|..||:....|   .:..||||.:|||||::||.
Zfish   701 PQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMAT---GSIPITVRHIESMIRMAEAH 762

  Fly   624 AKLECSNRVLERHVKEAFRLLNKSIIRVEQ 653
            |::...:.|||..|..|.|::.:|.|..::
Zfish   763 ARMHLRDYVLEDDVNMAIRVMLESFIDTQK 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	21/98 (21%)
		MCM	113..649	CDD:475121	194/562 (35%)
		MCM6_C	702..816	CDD:465688
mcm2	NP_775364.2	MCM2_N	57..170	CDD:403724	220/680 (32%)
		MCM_N	185..273	CDD:464206	20/91 (22%)
		MCM	279..788	CDD:214631	194/561 (35%)