DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and mcm-7

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_504199.1	Gene:	mcm-7 / 178831	WormBaseID:	WBGene00003159	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	205/694 - (29%)
Similarity:	326/694 - (46%)	Gaps:	113/694 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QDFLEEF---KEDGEIK---YTRPAASLESPDRCTLEVSFEDVEKYD----QNLATAIIEEYYHI 80
            :.|.:|:   .|||..|   |......:...|:..:.|:.:.:::.|    ..|:.||.......
Worm    18 RSFFDEYYVDNEDGSGKAFPYRDQVFEIARRDKQAIVVNVDHIKESDIPDALELSEAITSNTKRY 82

  Fly    81 YPFLCQSVSNYVKDRIGLKTQK-----DCY----------------------------------- 105
            ......::|:.::|.:|.|...     |.|
Worm    83 EVLFKDTISDMIQDYLGDKQAPVIDALDAYMFQRLHMDRNEGAANEEVSLQDKRKKYPPQLLQRF 147

  Fly   106 -VAFTEVPTRHK--VRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFK 167
             |.||.....|:  ||::..::||.|:.:.|.|:|...|.|.:....:.|..|..|:....:..:
Worm   148 EVYFTTDDAAHETCVRNIKATEIGHLVSMKGVVIRATEVKPCVEVMTYTCDTCAAEVYQPVKGMQ 212

  Fly   168 FTNPTICRNPVCSNRK---RFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVET 229
            ||.|..|.|..|...|   |..:.:..|.|:.||:::|||...::|.|.|||.:.:.:..|:...
Worm   213 FTPPVNCPNKECVEAKANGRLHMQLRGSKFVKFQELKIQELSEQVPVGSIPRTMTVHVYGEMTRK 277

  Fly   230 VQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACS 294
            ...|:....:|..:.:              ..|..:|..|:...|.|:|..:..|:
Worm   278 CNTGNVVHVSGVFLPI--------------MQSGFRPTGGLVADTYLEAHYINNLD--------- 319

  Fly   295 VQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRG 359
               ....|.|......||                   :.:..:.|:.|.:|:.|.|:|:.:||:.
Worm   320 ---DNPTFNGVQSAELEV-------------------LRRKGDNYETLAASIAPEIFGHVDVKKC 362

  Fly   360 ILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAA 424
            :|:...|| ...::....:||.|||.::|||..||||.|..|:..:||:.||:|:.||..|||||
Worm   363 LLMALVGG-NDNSSNGMKIRGCINVLMMGDPGVAKSQLLGYVNRLAPRSQYTTGRGSSGVGLTAA 426

  Fly   425 VVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNART 489
            |::|..:.:..:|.|||:|||.|||||||||||...|:.||||.|||||||||:||:..||||||
Worm   427 VMKDPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGIMTTLNART 491

  Fly   490 SILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHS----- 549
            :|:|||||..|||:.::|::||:.|.|.::|||||..::.|:.:...|..:|..|..:|.
Worm   492 AIIAAANPAYGRYNPNRSIEQNVDLPAALLSRFDLILLMQDKADRENDKILAEHITYVHQHGCHP 556

  Fly   550 NIEESVERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLE 614
            |.|:  :...:.|.:..|::..:.:.|.:.......:||.|..:| ||...|...|: ::.|.:.
Worm   557 NREK--KDLISLETLREYISLCKTYTPTVDPALRERIVEAYVEMR-RDARYSSDPTF-VSPRMIL 617

  Fly   615 SMIRLSEAMAKLECSNRVLERHVKEAFRLLN--KSIIRVEQPDI 656
            .::|::.|.|||..|..|.|..|:||.||:.  |..:|.||..|
Worm   618 GIVRMATARAKLRLSTIVDESDVEEALRLMQFAKDSLRPEQNKI 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	20/133 (15%)
		MCM	113..649	CDD:214631	179/547 (33%)
		MCM6_C	702..816	CDD:375690
mcm-7	NP_504199.1	MCM_N	16..178	CDD:291233	28/159 (18%)
		MCM	162..651	CDD:214631	177/538 (33%)
		P-loop_NTPase	385..524	CDD:304359	80/138 (58%)
		CarD_CdnL_TRCF	<619..715	CDD:294393	18/43 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820