Protein Alignment Mcm6 and mcm-6

DIOPT Version :10

• Sequence 1: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001023011.1
• Gene: mcm-6 / 176385
• WormBaseID: WBGene00003158
• Length: 810
• Species: Caenorhabditis elegans
• Alignment Length: 820
• Identity: 430/820 - (52%)
• Similarity: 566/820 - (69%)
• Gaps: 38/820 - (4%)

  Fly    12 RVKDEVGIRAQKLFQDFLEEFKED-GEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIE 75
            :|:|..|.|.|..|..||:.||:. .|..|......|..|::.|:.::.:.:.|:..||||.|..
 Worm    11 QVEDTDGTRVQNEFSKFLKSFKDQKNEFIYKSAMKELVQPEKNTIFINMQHLYKFSNNLATTIEL 75

  Fly    76 EYYHIYPFLCQSVSNYVKDRIGLKT-----QKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQV 135
            :||.:|||:|:::.....|......     :|..||:...:..:.|||:|:..|:|.|:||:||:
 Worm    76 QYYRVYPFMCEALHLATLDACDESERQQMFKKQLYVSLFNLDAKTKVRELSADKVGGLVRIAGQI 140

  Fly   136 VRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKI 200
            ||||||||||....|:|.||....|:|:|||::|.||.|.||.|.||.||.|||..|.|:|||||
 Worm   141 VRTHPVHPELSRACFVCEDCGVTTRDVQQQFRYTQPTKCANPQCMNRTRFSLDVNSSTFVDFQKI 205

  Fly   201 RIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAE--NSSR 263
            ||||||||||||.|||.|::|:|.|:|||||.||:.|..|||||:||::.|:..|.|||  |.:|
 Worm   206 RIQETQAELPRGSIPRTVDVIVRGEMVETVQPGDKCDIVGTLIVIPDIAQLSTPGLRAETSNQNR 270

  Fly   264 HKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGG-TDLPMSEVTAEDMKKQMTDAEWH 327
            .:..:..:|:|||||||:|:|.|:||||||.:|.|.:..|| ....:.|....|:..:|:..:..
 Worm   271 GRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTESLVGGDASGAVEETDYLDLWSKMSTEDRA 335

  Fly   328 KIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVA-KTTTEKTSLRGDINVCIVGDPS 391
            .:.:||.|:.:.:|::.||||:||||.|||.|:||...|||| |:..|.||||||||||:|||||
 Worm   336 TLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLLMLLGGVAKKSRDEGTSLRGDINVCLVGDPS 400

  Fly   392 TAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDK 456
            |||||.||.|.:|||||||||||||||||||||||:|||||:||||||||||||||:||||||||
 Worm   401 TAKSQVLKAVEEFSPRAIYTSGKASSAAGLTAAVVKDEESFEFVIEAGALMLADNGVCCIDEFDK 465

  Fly   457 MDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSR 521
            ||.:||||||||||||||||.:|||:||||||.||||||||:|||||||:.|:.|:|:|||||||
 Worm   466 MDLKDQVAIHEAMEQQTISITKAGVKATLNARASILAAANPVNGRYDRSRPLKYNVQMSAPIMSR 530

  Fly   522 FDLFFILVDECNEVVDYAIARKIVDLHSNIEESVER--AYTREEVLRYVTFARQFKPVISQEAGH 584
            |||||:||||||||.||||||:|:|.|..|.|..||  .|..:::.:|:.|||.|||.||.:|..
 Worm   531 FDLFFVLVDECNEVTDYAIARRILDNHRAISEHTERDSVYKIDDIKKYIAFARCFKPKISDKAAE 595

  Fly   585 MLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSII 649
            .||..|..||..|:..:..|:||||||||||::|||||:|:|.|...||..||::|..||||||:
 Worm   596 TLVREYKKLRMSDSNNAATSSWRITVRQLESLVRLSEALARLHCGKEVLVEHVEKAAELLNKSIV 660

  Fly   650 RVEQPDIHLDDDEGLDMDDGIQ-HDIDMENNGAAANVDENNGMDTSASGAVQKKKFTLSFEDYKN 713
            |||||||.||||   |.|:.|. .:.|.||.....::|.:...:.:....:.|.|  :||::||.
 Worm   661 RVEQPDIALDDD---DFDNNIMVVEADKENQRGDDSMDHDGEKENAPKIDIAKLK--ISFKEYKQ 720

  Fly   714 LSTMLVLHMRAEEARCEVEGND--TGIKRSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLI 776
            ||.:||||||::|   :.:|.|  .|:|:|.:|.|||..:...:|:|::...:|.:.|::|.|||
 Worm   721 LSDVLVLHMRSDE---DNQGEDEYDGVKQSALVEWYLSTIEADLETEEDFNVQKTICERVIHRLI 782

  Fly   777 YHDQVIIPLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVV 816
            :.|.|::.::               :.:||.|.||||||:
 Worm   783 HQDHVLLEVE---------------QGEDPTLCVHPNYVI 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	27/92 (29%)
		MCM	113..649	CDD:475121	337/541 (62%)
		MCM6_C	702..816	CDD:465688	41/115 (36%)
mcm-6	NP_001023011.1	MCM_N	21..115	CDD:464206	27/93 (29%)
		MCM	119..660	CDD:214631	337/540 (62%)
		MCM6_C	710..807	CDD:465688	42/116 (36%)