DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and mcm-5

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_497858.1	Gene:	mcm-5 / 175552	WormBaseID:	WBGene00003157	Length:	759	Species:	Caenorhabditis elegans

Alignment Length:	818	Identity:	235/818 - (28%)
Similarity:	385/818 - (47%)	Gaps:	165/818 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FQDFLEEFKEDG-------EIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYP 82
            |::|:.:|...|       ::|  |...|.|    ..||::...::.:|:::...:.:....:.|
Worm    39 FRNFIRDFSTGGFGMIYRDQLK--RNYFSHE----YRLEINLNHLKNFDEDIEMKLRKFPGKVLP 97

  Fly    83 FLCQSVSNYVKDRI------GLKTQKDCYVAFT--EVPTRHKVRDLTTSKIGTLIRISGQVVRTH 139
            .| :..:..|.|.|      |.:...|..|..|  |.||  .:|.:.::::..:::|||.:|...
Worm    98 AL-EEAAKIVADEITTPRPKGEEKLHDIQVTLTLDEYPT--SLRQVKSAQVSQVVKISGIIVAAA 159

  Fly   140 PVHPELVSGVFMCLDCQTEIRNVEQQFK-----FTNPTICRNPVCSNRKRFMLD-----VEKSLF 194
            .|..:.......|..|:..|.:|  ..|     |..|..|..|.....:|..:|     .:|...
Worm   160 QVRSKATKVTLQCRQCKHTIPDV--SIKPGLEGFALPRTCAAPQQGQMQRCPIDPYIMLPDKCEC 222

  Fly   195 LDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAE 259
            :|:|.:::||...::|.|.:||.:::.....|.:.|..|:|.    |::.|..:..|.
Worm   223 VDYQTLKLQENPEDVPHGEMPRHLQLFTERYLTDKVVPGNRV----TIVGVYSIKKLI------- 276

  Fly   260 NSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDA 324
                .|.| |...:.|::...:|.|...|         .|:..|.|:  .:..|.|:.:...|
Worm   277 ----QKKG-GDKSLQGIRTPYLRVLGIHM---------ETSGPGRTN--FTTFTPEEERMFKT-- 323

  Fly   325 EWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGD 389
                   :::.::.|:.:..|:.|||||:.::|:.|....|||..|...:..:.||||||.::||
Worm   324 -------LAQRKDAYELIAKSIAPSIYGSADIKKSIACLLFGGARKKLPDGITRRGDINVLLLGD 381

  Fly   390 PSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEF 454
            |.|||||.||.|...||..:|||||.||||||||:|:||.:|..|::|.||::|||.|:.|||||
Worm   382 PGTAKSQLLKFVEQVSPIGVYTSGKGSSAAGLTASVIRDPQSRSFIMEGGAMVLADGGVVCIDEF 446

  Fly   455 DKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIM 519
            |||.:.|:|||||||||||||||:||:..|||:|.|:|||||.:.||:|.|:. ..||.....|:
Worm   447 DKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVYGRWDESRG-DDNIDFMPTIL 510

  Fly   520 SRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVER------------------------AYT 560
            ||||:.:|:.|..:.:.|..:|:.::::|.|...:.||                        ..|
Worm   511 SRFDMIYIVKDTHDVLKDATLAKHVIEVHVNASAAKERDIAGVPKTATTDSDGVMTMFDTDGFLT 575

  Fly   561 REEVLRYVTFAR-QFKPVISQEAGHMLVENYGHLR----QRDTGTSGR----STWRITVRQLESM 616
            .|.:.::||:|| ...|.::.:|...||.:|..:|    ..|...||:    |...|||||||::
Worm   576 IEFLKKFVTYARLNCGPRLTPQASEKLVNHYVKMRNPVVNADAFKSGKKAHNSAIPITVRQLEAI 640

  Fly   617 IRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGA 681
            :|::|::||:|......::||:||.||...|.|..                            .|
Worm   641 VRIAESIAKMELQQFATDKHVEEALRLFRVSTIEA----------------------------AA 677

  Fly   682 AANVDENNGMDTSASGAV-------QKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIK 739
            ..|:....|..::|....       .||:|.        :.|.:..|:..::.          :.
Worm   678 TGNLAGVEGFTSTADQEALNRIEVQMKKRFA--------IGTHVSEHLIVQDF----------VA 724

  Fly   740 RSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIY 777
            |.:    |.|.:..::  .|.|:.|.:|.:|:..:::|
Worm   725 RQH----YRESLVKKV--IDNLVRRGDLQQKMQRKMLY 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	19/96 (20%)
		MCM	113..649	CDD:214631	194/578 (34%)
		MCM6_C	702..816	CDD:375690	13/76 (17%)
mcm-5	NP_497858.1	MCM_N	38..153	CDD:291233	25/122 (20%)
		MCM	134..673	CDD:214631	195/579 (34%)
		AAA	375..516	CDD:99707	87/141 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820