DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and mcm-2

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001022416.1	Gene:	mcm-2 / 174841	WormBaseID:	WBGene00003154	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	224/688 - (32%)
Similarity:	359/688 - (52%)	Gaps:	106/688 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKDE-VGIRAQKLFQDFLEEFKEDG--EIKYTRPAASLESPDRCTLEVSFEDV--EKYDQNLA-- 70
            |.|| |....::.|::||..|.|.|  :.||.:...|:.:.:|.:|||||.|:  :..:||::
Worm   159 VSDEAVAKEIERRFKNFLRSFHEPGNKQTKYIQMIKSMAADNRESLEVSFTDLSDDNGEQNISYF 223

  Fly    71 -------------TAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTT 122
                         .|..|...::|||..: |.|.:|.||            :::|....:|.|..
Worm   224 LPEAPNEMLAIMDRAATEVVMNMYPFYSR-VCNEIKVRI------------SQLPVEEDIRMLRQ 275

  Fly   123 SKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRN-VEQQFKFTNPTICRNPVCSNRKRFM 186
            ..:..|||.:|.|.....:.|:|....:.|:.|...:.. |:|..:...||||  |.|..:..|.
Worm   276 VHLNMLIRTAGVVTIASGILPQLAVVKYDCVACGYLLGPFVQQNDEEVRPTIC--PSCQGKGPFE 338

  Fly   187 LDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVL 251
            |:||.:::.::|:|.:||:..::..|.:||:.::||..:|.::.:.||..:.||...
Worm   339 LNVENTVYHNYQRITMQESPNKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYT-------- 395

  Fly   252 AGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAED 316
                            ...||          .|||:..|...:          |.:..:.:|.:|
Worm   396 ----------------NNFDG----------SLNYKQGFPVFN----------TLIHANHITNKD 424

  Fly   317 --MKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLR 379
              ...|:||.:...|.|:|:|.|:.|.:.||:.|||||:|:|||.|.|..|.|.||....|..||
Worm   425 KMASDQLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHRLR 489

  Fly   380 GDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLA 444
            |||||.:.|||.|||||||:..:..:||::.|:|:.:||.||||.|.|...:.::.:||||::||
Worm   490 GDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLA 554

  Fly   445 DNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQ 509
            |.|:|.|||||||..:|:.:||||||||:|||::||:..:|:||.:::||:|||.|||:.:::..
Worm   555 DKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFA 619

  Fly   510 QNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLH--------------SNIEESV--ERA 558
            :|:.|:.||:||||:..::.|..:.|.|..:|:.:|..|              ..:||..  ||.
Worm   620 ENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHPDAKKIVKEGDELEEDQMDERT 684

  Fly   559 YTR---EEVLR-YVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIR 618
            ..|   :::|| |:.:||: ..|.:.::........:..:|:....|...:   ||||.:|||||
Worm   685 GVRLIPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVA---ITVRHVESMIR 746

  Fly   619 LSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDI 656
            ||||.|||...:.|.:.....|.|::.:|.:..::..|
Worm   747 LSEAHAKLHLRSYVNDEDCAAAIRVMLESFVNTQKASI 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	28/102 (27%)
		MCM	113..649	CDD:214631	190/559 (34%)
		MCM6_C	702..816	CDD:375690
mcm-2	NP_001022416.1	MCM2_N	48..>103	CDD:289392
		MCM_N	171..286	CDD:291233	34/127 (27%)
		MCM	270..777	CDD:214631	190/555 (34%)
		AAA	461..639	CDD:99707	91/177 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920