DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm6 and Mcm7

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_032594.1	Gene:	Mcm7 / 17220	MGIID:	1298398	Length:	719	Species:	Mus musculus

Alignment Length:	692	Identity:	213/692 - (30%)
Similarity:	336/692 - (48%)	Gaps:	107/692 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRVKDEVGIRAQKLFQDFLEEFKEDGEI-----KYTRPAASLESPDRCTLEVSFEDVEKYDQNLA 70
            :.:|| ..|..:|: :.||:||..:.|:     ||......|...::..|.|..:|:.:.|..|.
Mouse     1 MALKD-YAIEKEKV-KKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELV 63

  Fly    71 TAIIE---EYYHIYPFLCQS-VSNYVKDRIGLKTQKDCYV------------------------- 106
            .:|.|   .|..::..:.|. :..|.:..:..|...|.|:
Mouse    64 DSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPS 128

  Fly   107 -------AFTEVPTRHK---VRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRN 161
                   .:...|:..|   :|::....:|.|:.:.|.|.|...|.|.:|...:.|..|..|...
Mouse   129 ELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQ 193

  Fly   162 VEQQFKFTNPTICRNPVC-SNRK--RFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILR 223
            ..|...|....:|.:..| :||.  |..|....|.|:.||:::|||...::|.|.|||::.::|.
Mouse   194 PIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLE 258

  Fly   224 SELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLK--ALGMRELNY 286
            .|.....|.||....||  |.:|   ||.                     ||.:  |.|:....|
Mouse   259 GENTRIAQPGDHVSVTG--IFLP---VLR---------------------TGFQQMAQGLLSETY 297

  Fly   287 RMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIY 351
            ..|.....:..:.....|.    .|:::|::|:             ..:.:.|:.|.:|:.|.||
Mouse   298 LEAHWIVKMTKSDDDVSGA----GELSSEELKQ-------------IAEEDFYEKLAASIAPEIY 345

  Fly   352 GNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKAS 416
            |:::||:.:||...|||.: :.:...:||:|::|::|||..||||.|..:...:||:.||:|:.|
Mouse   346 GHEDVKKALLLLLVGGVDQ-SPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGS 409

  Fly   417 SAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGV 481
            |..||||||:||..|.:..:|.|||:|||.|:|||||||||.:.|:.||||.|||||||||:||:
Mouse   410 SGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 474

  Fly   482 RATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVD 546
            ..|||||.||||||||..|||:..:||:||:||.|.::|||||.:::.|..:...|..:|:.|..
Mouse   475 LTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITY 539

  Fly   547 LHSNIE------ESVERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRST 605
            :|.:..      |.::....|    ||:....:.:|.:.:.....:...|..:| |:...|..:|
Mouse   540 VHQHSRQPPAQFEPLDMKLMR----RYIAMCHERQPTVPESLADYITAAYVEMR-REARASKDAT 599

  Fly   606 WRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKS 647
            : .:.|.|.:::|||.|:|:|...:.|.:..|.||.||:..|
Mouse   600 Y-TSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	21/124 (17%)
		MCM	113..649	CDD:214631	187/549 (34%)
		MCM6_C	702..816	CDD:375690
Mcm7	NP_032594.1	MCM_N	12..165	CDD:291233	27/153 (18%)
		MCM	145..641	CDD:214631	187/546 (34%)
		P-loop_NTPase	376..515	CDD:304359	82/138 (59%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000250	521..564		9/46 (20%)
		Interaction with ATRIP. /evidence=ECO:0000250	577..719		20/66 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820