DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm6 and Mcm6

DIOPT Version :9

Sequence 1:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_032593.1	Gene:	Mcm6 / 17219	MGIID:	1298227	Length:	821	Species:	Mus musculus

Alignment Length:	814	Identity:	516/814 - (63%)
Similarity:	640/814 - (78%)	Gaps:	20/814 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKDEVGIRAQKLFQDFLEEFK-EDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEE 76
            |:|||..:.||||.||||||: .||||||.:.|..|..|:|.||.|||.|:|:::|.|:|.|.||
Mouse    18 VRDEVAEKCQKLFLDFLEEFQGSDGEIKYLQFAEELIRPERNTLVVSFADLEQFNQQLSTTIQEE 82

  Fly    77 YYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPV 141
            :|.:||:||:::..:||||..:...||.||||.::|||||:|:||:|:||.|.||||||||||||
Mouse    83 FYRVYPYLCRALKTFVKDRKEIPFAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPV 147

  Fly   142 HPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQ 206
            |||||||.|:||||||.|::||||||:|.|.|||||||:|||||:||..||.|:||||:||||||
Mouse   148 HPELVSGTFLCLDCQTVIKDVEQQFKYTQPNICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQ 212

  Fly   207 AELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEG-- 269
            ||||||.|||::|:|||:|.||:.|||||.||||.||||||||.|:..|.|||.:||....:|
Mouse   213 AELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYE 277

  Fly   270 MDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSK 334
            .:|:.||:|||:|:|:||:.||||.|..|..||||.:|...|.|||.:|.|||..||.|::|||:
Mouse   278 TEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQ 342

  Fly   335 DRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLK 399
            |:|||.||.:||||:|:||||||||:||..||||.|||.|.||||||||||||||||||||||||
Mouse   343 DKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLK 407

  Fly   400 QVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVA 464
            .|.:|||||:||||||||||||||||||||||.:||||||||||||||:||||||||||.|||||
Mouse   408 HVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVA 472

  Fly   465 IHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILV 529
            ||||||||||||.:|||:|||||||||||||||::|.|||||||:|||.||||||||||||||||
Mouse   473 IHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILV 537

  Fly   530 DECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLR 594
            ||||||.||||||:||||||.||||::|.|:.:::.||:.|||||||.||:|:...:||.|..||
Mouse   538 DECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLR 602

  Fly   595 QRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLD 659
            |||.....:|:||||||||||||||||:||::.|.:.|..:|||||||||||||||||.||::||
Mouse   603 QRDGSGVTKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLD 667

  Fly   660 DDEGLDM--DDGIQHDIDMENNGAA---ANVDENNGMDTSAS-GAVQKKKFTLSFEDYKNLSTML 718
            .:|.:.|  |:| |..:    ||.|   |.|:..||....|| ..|.|....|.|.:|..:|.::
Mouse   668 QEEEIQMETDEG-QGGV----NGHADSPAPVNRFNGSSEDASQETVSKPSLRLGFAEYCRISNLI 727

  Fly   719 VLHMRAEEARCEVEGNDTGIKRSNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVII 783
            |||:|    :.|.|.:::.:|||.:|.|||:::..:|:||:|||::|.:|||::.||.::|.|:|
Mouse   728 VLHLR----KMEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKTIIEKVVHRLTHYDHVLI 788

  Fly   784 PLKTSTLKPRIQVQKDFVEEDDPLLVVHPNYVVE 817
            .|..:.||...:..:.:  |:||.|||:|||::|
Mouse   789 ELTQAGLKGSSEGSESY--EEDPYLVVNPNYLLE 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	44/84 (52%)
		MCM	113..649	CDD:214631	393/537 (73%)
		MCM6_C	702..816	CDD:375690	44/113 (39%)
Mcm6	NP_032593.1	MCM_N	29..139	CDD:291233	61/110 (55%)
		MCM	119..657	CDD:214631	395/539 (73%)
		P-loop_NTPase	<447..534	CDD:304359	76/86 (88%)
		Arginine finger	528..531		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..708		12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849783
Domainoid	1	1.000	383	1.000	Domainoid score	I825
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4322
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I294
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53901
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	1	1.000	-	-		oto95105
orthoMCL	1	0.900	-	-		OOG6_101983
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R696
SonicParanoid	1	1.000	-	-		X2150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800